Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats

Shinji Tokuda, Toshihiko Fukuda, Yutaro Kobayashi, Mitsuru Tanaka, Toshiro Matsui

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC50 value of 0:40 ± 0:12mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

本文言語英語
ページ(範囲)828-830
ページ数3
ジャーナルBioscience, Biotechnology and Biochemistry
76
4
DOI
出版ステータス出版済み - 2012

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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