### 抄録

The irreversible electroporation (IRE) is a novel method to ablate abnormal cells by applying a high voltage between two electrodes that are stuck into abnormal tissues. One of the advantages of the IRE is that the extracellular matrix (ECM) may be kept intact, which is favorable for healing. For a successful IRE, it is therefore important to avoid thermal damage of ECM resulted from the Joule heating within the tissue. A three-dimensional (3-D) analysis was conducted in this study to predict temperature rise during the IRE. The equation of electric field and the heat conduction equation were solved numerically by a finite element method. It was clarified that the highest temperature rise occurred at the base of electrodes adjacent to the insulated surface. The result was significantly different from a two-dimensional (2-D) analysis due to end effects, suggesting that the 3-D analysis is required to determine the optimal condition.

元の言語 | 英語 |
---|---|

ホスト出版物のタイトル | ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011 |

出版物ステータス | 出版済み - 12 1 2011 |

イベント | ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011 - Honolulu, HI, 米国 継続期間: 3 13 2011 → 3 17 2011 |

### 出版物シリーズ

名前 | ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011 |
---|

### その他

その他 | ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011 |
---|---|

国 | 米国 |

市 | Honolulu, HI |

期間 | 3/13/11 → 3/17/11 |

### Fingerprint

### All Science Journal Classification (ASJC) codes

- Energy Engineering and Power Technology

### これを引用

*ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011*(ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011).

**Effect of three-dimensional electric field and heat conduction to electrodes on the temperature rise during irreversible electroporation.** / Nomura, Seiji; Kurata, Kosaku; Takamatsu, Hiroshi.

研究成果: 著書/レポートタイプへの貢献 › 会議での発言

*ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011.*ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011, ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011, Honolulu, HI, 米国, 3/13/11.

}

TY - GEN

T1 - Effect of three-dimensional electric field and heat conduction to electrodes on the temperature rise during irreversible electroporation

AU - Nomura, Seiji

AU - Kurata, Kosaku

AU - Takamatsu, Hiroshi

PY - 2011/12/1

Y1 - 2011/12/1

N2 - The irreversible electroporation (IRE) is a novel method to ablate abnormal cells by applying a high voltage between two electrodes that are stuck into abnormal tissues. One of the advantages of the IRE is that the extracellular matrix (ECM) may be kept intact, which is favorable for healing. For a successful IRE, it is therefore important to avoid thermal damage of ECM resulted from the Joule heating within the tissue. A three-dimensional (3-D) analysis was conducted in this study to predict temperature rise during the IRE. The equation of electric field and the heat conduction equation were solved numerically by a finite element method. It was clarified that the highest temperature rise occurred at the base of electrodes adjacent to the insulated surface. The result was significantly different from a two-dimensional (2-D) analysis due to end effects, suggesting that the 3-D analysis is required to determine the optimal condition.

AB - The irreversible electroporation (IRE) is a novel method to ablate abnormal cells by applying a high voltage between two electrodes that are stuck into abnormal tissues. One of the advantages of the IRE is that the extracellular matrix (ECM) may be kept intact, which is favorable for healing. For a successful IRE, it is therefore important to avoid thermal damage of ECM resulted from the Joule heating within the tissue. A three-dimensional (3-D) analysis was conducted in this study to predict temperature rise during the IRE. The equation of electric field and the heat conduction equation were solved numerically by a finite element method. It was clarified that the highest temperature rise occurred at the base of electrodes adjacent to the insulated surface. The result was significantly different from a two-dimensional (2-D) analysis due to end effects, suggesting that the 3-D analysis is required to determine the optimal condition.

UR - http://www.scopus.com/inward/record.url?scp=84860899786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860899786&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84860899786

SN - 9780791838921

T3 - ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011

BT - ASME/JSME 2011 8th Thermal Engineering Joint Conference, AJTEC 2011

ER -