Effect of transcranial magnetic stimulation on P300 of event-related potential

Masakuni Iwahashi, Yoshinori Katayama, Shoogo Ueno, Keiji Iramina

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

20 被引用数 (Scopus)

抄録

When the odd stimulation is presented, the positive component of electroencephalograph is induced at around 300 ms after the odd stimulation. This positive component is called P300. Many studies suggest that P300 may result from the summation of activity from multiple generators located in widespread cortical and subcortical areas. However, there is still no conclusive indication of the sources of P300. In this paper, we focus on the left supramaginal gyrus as one of the sources of P300. We investigated the temporal aspect of this area using TMS (transcranial magnetic stimulation). We investigated the relationship between the latency of the P300 and an effect of TMS when the left supramarginal gyrus was stimulated by TMS. In our previous study, we reported a method of removing stimulus artifact during TMS with Sample-and-Hold circuit and electroencephalogram (EEG) activity evoked by TMS could be measured successfully. In addition to this method, independent component analysis (ICA) was also applied to recorded EEG data in order to remove the stimulus artifact by off-line analysis. By using these methods, short latency (< 15 ms) EEG responses to TMS could be obtained. We stimulated the left supramarginal gyrus using a figure-eight coil during auditory oddball task. The TMS at 150 ms and 200 ms after the oddball sounds were presented. When the TMS was applied at 200 ms after the oddball stimulation, the peak response of P300 was delayed around 50 ms. Difference of the peak latency between the control measurement and the case of TMS applying at 150 ms was not significant. However, the differences of the peak latency of the control measurement and the peak latency of the measurement in the cases of TMS applying at 200 ms and 250 ms was significant (p<0.05). We considered that this delay was due to inhibiting to recognize the target stimulation.

本文言語英語
ホスト出版物のタイトルProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
ホスト出版物のサブタイトルEngineering the Future of Biomedicine, EMBC 2009
出版社IEEE Computer Society
ページ1359-1362
ページ数4
ISBN(印刷版)9781424432967
DOI
出版ステータス出版済み - 1 1 2009
イベント31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, 米国
継続期間: 9 2 20099 6 2009

出版物シリーズ

名前Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

その他

その他31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
国/地域米国
CityMinneapolis, MN
Period9/2/099/6/09

All Science Journal Classification (ASJC) codes

  • 細胞生物学
  • 発生生物学
  • 生体医工学
  • 医学(全般)

フィンガープリント

「Effect of transcranial magnetic stimulation on P300 of event-related potential」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル