Effect of wood, bark and leaf extracts of Macaranga trees on cytotoxic activity in some cancer and normal cell lines

Enos Tangke Arung, Rudianto Amirta, Qinchang Zhu, Yhiya Amen, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

The genus of Macaranga (Euphorbiacaceae) has 250 species of which 160 species are endemic in Kalimantan and New Guinea. They grow as pioneer trees and are used as traditional medicines in the Asian regions. This experiment concerns cytotoxicity in both cancer and normal cells of their methanol extracts from wood, bark and leaf parts. Some of them have not yet reported its cytotoxic activity in those cell lines. The 21 methanol extracts were prepared from seven Macaranga tree species (Macaranga bancana, Macaranga gigantea, Macaranga hullettii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa and Macaranga triloba). The MTT assay was used to evaluate cytotoxic activity of extracts in cancer cell lines [human breast cancer (MCF-7), mouse melanoma (B16 melanoma), human colon cancer (HCT116), human cervical adenocarcinoma (HeLa)] and normal cell lines [human normal fibroblast (TIG-1) and normal human dermal fibroblast (NHDF)]. The leaf extracts of M. pruinosa, M. tanarius, M. trichocarpa showed more cytotoxicity than wood and bark in all cancer cell lines. In addition, the 5-fluorouracil was used as a positive control. These findings indicated the extracts from leaves of M. pruinosa, M. tanarius and M. trichocarpa had more potential than wood and bark parts to be developed as anti-cancer agents.

元の言語英語
ページ(範囲)115-119
ページ数5
ジャーナルJournal of the Indian Academy of Wood Science
15
発行部数2
DOI
出版物ステータス出版済み - 12 1 2018

Fingerprint

Macaranga
leaf extracts
bark
cancer
Wood
Macaranga tanarius
Cells
cell lines
neoplasms
Fibroblasts
Cytotoxicity
Methanol
extracts
melanoma
methanol
Macaranga triloba
fibroblasts
cytotoxicity
Fluorouracil
Medicine

All Science Journal Classification (ASJC) codes

  • Forestry
  • Biomaterials
  • Plant Science

これを引用

Effect of wood, bark and leaf extracts of Macaranga trees on cytotoxic activity in some cancer and normal cell lines. / Arung, Enos Tangke; Amirta, Rudianto; Zhu, Qinchang; Amen, Yhiya; Shimizu, Kuniyoshi.

:: Journal of the Indian Academy of Wood Science, 巻 15, 番号 2, 01.12.2018, p. 115-119.

研究成果: ジャーナルへの寄稿記事

@article{8c1c58c4b58f46e3bb5fd25f4f5c55bc,
title = "Effect of wood, bark and leaf extracts of Macaranga trees on cytotoxic activity in some cancer and normal cell lines",
abstract = "The genus of Macaranga (Euphorbiacaceae) has 250 species of which 160 species are endemic in Kalimantan and New Guinea. They grow as pioneer trees and are used as traditional medicines in the Asian regions. This experiment concerns cytotoxicity in both cancer and normal cells of their methanol extracts from wood, bark and leaf parts. Some of them have not yet reported its cytotoxic activity in those cell lines. The 21 methanol extracts were prepared from seven Macaranga tree species (Macaranga bancana, Macaranga gigantea, Macaranga hullettii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa and Macaranga triloba). The MTT assay was used to evaluate cytotoxic activity of extracts in cancer cell lines [human breast cancer (MCF-7), mouse melanoma (B16 melanoma), human colon cancer (HCT116), human cervical adenocarcinoma (HeLa)] and normal cell lines [human normal fibroblast (TIG-1) and normal human dermal fibroblast (NHDF)]. The leaf extracts of M. pruinosa, M. tanarius, M. trichocarpa showed more cytotoxicity than wood and bark in all cancer cell lines. In addition, the 5-fluorouracil was used as a positive control. These findings indicated the extracts from leaves of M. pruinosa, M. tanarius and M. trichocarpa had more potential than wood and bark parts to be developed as anti-cancer agents.",
author = "Arung, {Enos Tangke} and Rudianto Amirta and Qinchang Zhu and Yhiya Amen and Kuniyoshi Shimizu",
year = "2018",
month = "12",
day = "1",
doi = "10.1007/s13196-018-0215-4",
language = "English",
volume = "15",
pages = "115--119",
journal = "Journal of the Indian Academy of Wood Science",
issn = "0972-172X",
publisher = "Springer India",
number = "2",

}

TY - JOUR

T1 - Effect of wood, bark and leaf extracts of Macaranga trees on cytotoxic activity in some cancer and normal cell lines

AU - Arung, Enos Tangke

AU - Amirta, Rudianto

AU - Zhu, Qinchang

AU - Amen, Yhiya

AU - Shimizu, Kuniyoshi

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The genus of Macaranga (Euphorbiacaceae) has 250 species of which 160 species are endemic in Kalimantan and New Guinea. They grow as pioneer trees and are used as traditional medicines in the Asian regions. This experiment concerns cytotoxicity in both cancer and normal cells of their methanol extracts from wood, bark and leaf parts. Some of them have not yet reported its cytotoxic activity in those cell lines. The 21 methanol extracts were prepared from seven Macaranga tree species (Macaranga bancana, Macaranga gigantea, Macaranga hullettii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa and Macaranga triloba). The MTT assay was used to evaluate cytotoxic activity of extracts in cancer cell lines [human breast cancer (MCF-7), mouse melanoma (B16 melanoma), human colon cancer (HCT116), human cervical adenocarcinoma (HeLa)] and normal cell lines [human normal fibroblast (TIG-1) and normal human dermal fibroblast (NHDF)]. The leaf extracts of M. pruinosa, M. tanarius, M. trichocarpa showed more cytotoxicity than wood and bark in all cancer cell lines. In addition, the 5-fluorouracil was used as a positive control. These findings indicated the extracts from leaves of M. pruinosa, M. tanarius and M. trichocarpa had more potential than wood and bark parts to be developed as anti-cancer agents.

AB - The genus of Macaranga (Euphorbiacaceae) has 250 species of which 160 species are endemic in Kalimantan and New Guinea. They grow as pioneer trees and are used as traditional medicines in the Asian regions. This experiment concerns cytotoxicity in both cancer and normal cells of their methanol extracts from wood, bark and leaf parts. Some of them have not yet reported its cytotoxic activity in those cell lines. The 21 methanol extracts were prepared from seven Macaranga tree species (Macaranga bancana, Macaranga gigantea, Macaranga hullettii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa and Macaranga triloba). The MTT assay was used to evaluate cytotoxic activity of extracts in cancer cell lines [human breast cancer (MCF-7), mouse melanoma (B16 melanoma), human colon cancer (HCT116), human cervical adenocarcinoma (HeLa)] and normal cell lines [human normal fibroblast (TIG-1) and normal human dermal fibroblast (NHDF)]. The leaf extracts of M. pruinosa, M. tanarius, M. trichocarpa showed more cytotoxicity than wood and bark in all cancer cell lines. In addition, the 5-fluorouracil was used as a positive control. These findings indicated the extracts from leaves of M. pruinosa, M. tanarius and M. trichocarpa had more potential than wood and bark parts to be developed as anti-cancer agents.

UR - http://www.scopus.com/inward/record.url?scp=85057039260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057039260&partnerID=8YFLogxK

U2 - 10.1007/s13196-018-0215-4

DO - 10.1007/s13196-018-0215-4

M3 - Article

VL - 15

SP - 115

EP - 119

JO - Journal of the Indian Academy of Wood Science

JF - Journal of the Indian Academy of Wood Science

SN - 0972-172X

IS - 2

ER -