TY - JOUR
T1 - Effect of wood, bark and leaf extracts of Macaranga trees on cytotoxic activity in some cancer and normal cell lines
AU - Arung, Enos Tangke
AU - Amirta, Rudianto
AU - Zhu, Qinchang
AU - Amen, Yhiya
AU - Shimizu, Kuniyoshi
N1 - Funding Information:
A part of this work was financially supported by Islamic Development Bank (IDB) Project for Mulawarman University 2018 (No. 2248/UN17.11/PL/2018) and the Grant of Mulawarman University Research of Excellent Program (UNMUL PUPT—Grant Nos. 166/UN17.16/PG/2015 and 104/UN17.41/LT/2016) provided by the Directorate General of Higher Education, the Ministry of Research, Technology, and Higher Education of Indonesia (Kemenristekdikti). The authors declare that they have no conflict of interest.
Funding Information:
Acknowledgements A part of this work was financially supported by Islamic Development Bank (IDB) Project for Mulawarman University 2018 (No. 2248/UN17.11/PL/2018) and the Grant of Mulawarman University Research of Excellent Program (UNMUL PUPT—Grant Nos. 166/UN17.16/PG/2015 and 104/UN17.41/LT/2016) provided by the Directorate General of Higher Education, the Ministry of Research, Technology, and Higher Education of Indonesia (Kemenristekdikti).
Publisher Copyright:
© 2018, Indian Academy of Wood Science.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The genus of Macaranga (Euphorbiacaceae) has 250 species of which 160 species are endemic in Kalimantan and New Guinea. They grow as pioneer trees and are used as traditional medicines in the Asian regions. This experiment concerns cytotoxicity in both cancer and normal cells of their methanol extracts from wood, bark and leaf parts. Some of them have not yet reported its cytotoxic activity in those cell lines. The 21 methanol extracts were prepared from seven Macaranga tree species (Macaranga bancana, Macaranga gigantea, Macaranga hullettii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa and Macaranga triloba). The MTT assay was used to evaluate cytotoxic activity of extracts in cancer cell lines [human breast cancer (MCF-7), mouse melanoma (B16 melanoma), human colon cancer (HCT116), human cervical adenocarcinoma (HeLa)] and normal cell lines [human normal fibroblast (TIG-1) and normal human dermal fibroblast (NHDF)]. The leaf extracts of M. pruinosa, M. tanarius, M. trichocarpa showed more cytotoxicity than wood and bark in all cancer cell lines. In addition, the 5-fluorouracil was used as a positive control. These findings indicated the extracts from leaves of M. pruinosa, M. tanarius and M. trichocarpa had more potential than wood and bark parts to be developed as anti-cancer agents.
AB - The genus of Macaranga (Euphorbiacaceae) has 250 species of which 160 species are endemic in Kalimantan and New Guinea. They grow as pioneer trees and are used as traditional medicines in the Asian regions. This experiment concerns cytotoxicity in both cancer and normal cells of their methanol extracts from wood, bark and leaf parts. Some of them have not yet reported its cytotoxic activity in those cell lines. The 21 methanol extracts were prepared from seven Macaranga tree species (Macaranga bancana, Macaranga gigantea, Macaranga hullettii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa and Macaranga triloba). The MTT assay was used to evaluate cytotoxic activity of extracts in cancer cell lines [human breast cancer (MCF-7), mouse melanoma (B16 melanoma), human colon cancer (HCT116), human cervical adenocarcinoma (HeLa)] and normal cell lines [human normal fibroblast (TIG-1) and normal human dermal fibroblast (NHDF)]. The leaf extracts of M. pruinosa, M. tanarius, M. trichocarpa showed more cytotoxicity than wood and bark in all cancer cell lines. In addition, the 5-fluorouracil was used as a positive control. These findings indicated the extracts from leaves of M. pruinosa, M. tanarius and M. trichocarpa had more potential than wood and bark parts to be developed as anti-cancer agents.
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U2 - 10.1007/s13196-018-0215-4
DO - 10.1007/s13196-018-0215-4
M3 - Article
AN - SCOPUS:85057039260
VL - 15
SP - 115
EP - 119
JO - Journal of the Indian Academy of Wood Science
JF - Journal of the Indian Academy of Wood Science
SN - 0972-172X
IS - 2
ER -
