Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection

Yasunori Sawayama, Masafumi Tatsukawa, Kensuke Kikuchi, Shinji Maeda, Hachiro Ohnishi, Norihiro Furusyo, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

To investigate the effect of levofloxacin on carotid atherosclerosis, patients with hypercholesterolemia whose carotid atherosclerosis was not improved by probucol therapy (500 mg/day) for 24 months were enrolled. All patients were seropositive for anti C. pneumoniae IgA and/or IgG. Carotid atherosclerosis was evaluated by ultrasonic measurement of the maximum intima-media thickness (Max-IMT). All subjects were prescribed three courses of levofloxacin (each course, 400 mg/day for 2 weeks, followed by 14 days off drug treatment). At 12 months after combined therapy with probucol and levofloxacin, Max-IMT was significantly decreased compared with the value before treatment (P < 0.01). These results suggest that the combination therapy was effective for improving carotid atherosclerosis in C. pneumoniae-seropositive patients.

元の言語英語
ページ(範囲)92-98
ページ数7
ジャーナルJournal of Infection and Chemotherapy
13
発行部数2
DOI
出版物ステータス出版済み - 1 1 2007

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Probucol
Chlamydophila pneumoniae
Chlamydia Infections
Levofloxacin
Carotid Artery Diseases
Therapeutics
Hypercholesterolemia
Ultrasonics
Immunoglobulin A
Immunoglobulin G
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Sawayama, Y., Tatsukawa, M., Kikuchi, K., Maeda, S., Ohnishi, H., Furusyo, N., & Hayashi, J. (2007). Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection. Journal of Infection and Chemotherapy, 13(2), 92-98. https://doi.org/10.1007/s10156-007-0510-2

Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection. / Sawayama, Yasunori; Tatsukawa, Masafumi; Kikuchi, Kensuke; Maeda, Shinji; Ohnishi, Hachiro; Furusyo, Norihiro; Hayashi, Jun.

:: Journal of Infection and Chemotherapy, 巻 13, 番号 2, 01.01.2007, p. 92-98.

研究成果: ジャーナルへの寄稿記事

Sawayama, Y, Tatsukawa, M, Kikuchi, K, Maeda, S, Ohnishi, H, Furusyo, N & Hayashi, J 2007, 'Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection', Journal of Infection and Chemotherapy, 巻. 13, 番号 2, pp. 92-98. https://doi.org/10.1007/s10156-007-0510-2
Sawayama, Yasunori ; Tatsukawa, Masafumi ; Kikuchi, Kensuke ; Maeda, Shinji ; Ohnishi, Hachiro ; Furusyo, Norihiro ; Hayashi, Jun. / Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection. :: Journal of Infection and Chemotherapy. 2007 ; 巻 13, 番号 2. pp. 92-98.
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