Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters

T. Tsujiuchi, Kazuhiro Mizumoto, M. Tsutsumi, A. Denda, T. Amanuma, S. Kondoh, Y. Konishi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Effects of 3-aminobenzamide (ABA) on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated in Syrian hamsters. Animals were given BOP at a dose of 70 mg/kg body weight by subcutaneous injection and following a 2-week recovery period, were administered basal diet or basal diet containing 0.5, 0.75 and 1.5% ABA for 30 weeks. While the incidences of resultant pancreatic lesions, including hyperplasia, atypical hyperplasia and carcinoma, induced by BOP were not significantly influenced by ABA treatment, the mean numbers of those pancreatic lesions were significantly decreased in a dose-dependent way. The results therefore suggested the possible involvement of poly(ADP-ribosyl)ation in the post-initiation phase of pancreatic carcinogenesis in hamsters.

元の言語英語
ページ(範囲)61-66
ページ数6
ジャーナルCancer Letters
61
発行部数1
DOI
出版物ステータス出版済み - 12 9 1991

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nitrosobis(2-oxopropyl)amine
Mesocricetus
Carcinogenesis
Hyperplasia
Diet
Subcutaneous Injections
Cricetinae
Adenosine Diphosphate
Body Weight
Carcinoma
Incidence
3-aminobenzamide

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters. / Tsujiuchi, T.; Mizumoto, Kazuhiro; Tsutsumi, M.; Denda, A.; Amanuma, T.; Kondoh, S.; Konishi, Y.

:: Cancer Letters, 巻 61, 番号 1, 09.12.1991, p. 61-66.

研究成果: ジャーナルへの寄稿記事

Tsujiuchi, T. ; Mizumoto, Kazuhiro ; Tsutsumi, M. ; Denda, A. ; Amanuma, T. ; Kondoh, S. ; Konishi, Y. / Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters. :: Cancer Letters. 1991 ; 巻 61, 番号 1. pp. 61-66.
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abstract = "Effects of 3-aminobenzamide (ABA) on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated in Syrian hamsters. Animals were given BOP at a dose of 70 mg/kg body weight by subcutaneous injection and following a 2-week recovery period, were administered basal diet or basal diet containing 0.5, 0.75 and 1.5{\%} ABA for 30 weeks. While the incidences of resultant pancreatic lesions, including hyperplasia, atypical hyperplasia and carcinoma, induced by BOP were not significantly influenced by ABA treatment, the mean numbers of those pancreatic lesions were significantly decreased in a dose-dependent way. The results therefore suggested the possible involvement of poly(ADP-ribosyl)ation in the post-initiation phase of pancreatic carcinogenesis in hamsters.",
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T1 - Effects of 3-aminobenzamide on the post-initiation phase of N-nitrosobis(2-oxopropyl)amine induced pancreatic carcinogenesis in Syrian hamsters

AU - Tsujiuchi, T.

AU - Mizumoto, Kazuhiro

AU - Tsutsumi, M.

AU - Denda, A.

AU - Amanuma, T.

AU - Kondoh, S.

AU - Konishi, Y.

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AB - Effects of 3-aminobenzamide (ABA) on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated in Syrian hamsters. Animals were given BOP at a dose of 70 mg/kg body weight by subcutaneous injection and following a 2-week recovery period, were administered basal diet or basal diet containing 0.5, 0.75 and 1.5% ABA for 30 weeks. While the incidences of resultant pancreatic lesions, including hyperplasia, atypical hyperplasia and carcinoma, induced by BOP were not significantly influenced by ABA treatment, the mean numbers of those pancreatic lesions were significantly decreased in a dose-dependent way. The results therefore suggested the possible involvement of poly(ADP-ribosyl)ation in the post-initiation phase of pancreatic carcinogenesis in hamsters.

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