Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice

Akiko Matsumoto, Toshihiro Kawamoto, Fumihiro Mutoh, Toyohi Isse, Tsunehiro Oyama, Kyoko Kitagawa, Keiichi I. Nakayama, Masayoshi Ichiba

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)


Objective The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian countries, and the mutated ALDH2 protein derived from ALDH2*2 lacks the ability of acetaldehyde metabolization. Our aim was to determine the consequences of the ALDH2 polymorphism on ethanol-administered liver tissue. Methods Aldh2+/+, +/-, and -/- mice were fed with ethanol solution and standard hard feed for 5 weeks. Results The serum alanine aminotransferase (ALT) level in the Aldh2-/- mice clearly decreased upon ethanol feeding, in contrast to Aldh2+/+ mice, in which the ALT level was unchanged. The levels of malondialdehyde, phospho extracellular signal-regulated kinase 2, and tumor necrosis factor-alpha in the liver tissue all correlated with the ALT level. Conclusion These findings suggest that ethanol intake in the presence of inactive ALDH2 decreases the serum ALT level following a decrease in oxidative stress and tumor necrosis factor-alpha secretion.

ジャーナルPharmacogenetics and Genomics
出版物ステータス出版済み - 10 1 2008


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)


Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., ... Ichiba, M. (2008). Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice. Pharmacogenetics and Genomics, 18(10), 847-852. https://doi.org/10.1097/FPC.0b013e328307a0a9