Effects of a new calcium antagonist, CD-832, on experimental coronary artery spasm in miniature pigs

Teisuke Takahashi, Thoru Fukai, Hiroshi Hata, Hiromitu Kasuya, Takeshi Kuga, Kensuke Egashira, Akira Takeshita

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

The effects of a new calcium antagonist, CD-832, on experimental coronary artery spasms were studied in Göttingen miniature pigs. Pigs underwent endothelial denudation at the left anterior descending coronary artery using a balloon catheter. Changes in the diameter of the denuded and nondenuded site in response to an intracoronary administration of serotonin (10 μg/kg) or histamine (10 μg/kg) were assessed quantitatively by selective coronary arteriography 1 week after endothelial denudation. Percent reductions of the coronary artery diameter induced by serotonin or histamine in the denuded site were significantly greater than those in the nondenuded site (p<0.01). Coronary artery spasm induced by serotonin or histamine in the denuded site was attenuated in a dose-dependent manner by intravenous infusion of CD-832 (10 and 30 μg/kg/min) or nifedipine (1 and 3 μg/kg/min). The degrees of inhibition of coronary artery spasm by CD-832 were similar to those produced by nifedipine. CD-832 and nifedipine at the high dose caused comparable increases in the basal coronary artery diameter. These results suggest that CD-832 may be a useful drug for the treatment of coronary artery spasm.

本文言語英語
ページ(範囲)265-271
ページ数7
ジャーナルCardiovascular Drugs and Therapy
7
2
DOI
出版ステータス出版済み - 4 1 1993

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

フィンガープリント 「Effects of a new calcium antagonist, CD-832, on experimental coronary artery spasm in miniature pigs」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル