Effects of adenosine A1- and A2A-receptor agonists on enhancement of dopamine release from the striatum in methamphetamine-sensitized rats

A. Yoshimatsu, T. Shimazoe, A. Kawashimo, T. Shuto, Y. Doi, T. Fukumoto, S. Watanabe

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

We report here both adenosine A1- and A2A-receptor agonists inhibit the expression of methamphetamine (MAP)-induced behavioral sensitization in rats. Animals were treated with MAP (1.0 mg/kg, i.p.) every 3 days with a total of 5 administrations. The augmentation of dopamine release from the striatum was demonstrated by MAP re-administration (0.5 mg/kg, i.p.) after 7-day withdrawal by microdialysis. The augmentation of dopamine release was inhibited by pre-treatment not with N6-cyclohexyladenosine (0.01 mg/kg, i.p.) but by with 2-p-(2-carboxyethyl)phenethylamino-5′-N-ethylcarboxy-amide adenosine (0.1 mg/kg, i.p.). These results suggested that adenosine A1 and A2A receptors play an inhibitory role in sensitization via different mechanisms.

本文言語英語
ページ(範囲)254-257
ページ数4
ジャーナルJapanese Journal of Pharmacology
86
2
DOI
出版ステータス出版済み - 2001

All Science Journal Classification (ASJC) codes

  • 薬理学

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「Effects of adenosine A<sub>1</sub>- and A<sub>2A</sub>-receptor agonists on enhancement of dopamine release from the striatum in methamphetamine-sensitized rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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