Effects of adrenomedullin and PAMP on membrane potential and neurotransmission

Kenichi Goto, Koji Fujii, Uran Onaka, Isao Abe, Masatoshi Fujishima

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

The effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) on membrane potential and sympathetic neurotransmission were studied in rat mesenteric arteries by using microelectrodes. AM (10-7 M) but not PAMP (10-6 M) produced membrane hyperpolarization, which was abolished by high K solution or by glibenclamide, an ATP-sensitive K+ (KATP) channel blocker. Neither AM nor PAMP affected excitatory junction potentials, a measure of sympathetic, purinergic neurotransmission. These findings suggest that AM hyperpolarizes the membrane via activation of KATP channels, which may contribute to the vasodilatory action of AM, whereas the mechanisms of the vasodepressor action of PAMP remain unclear. Copyright (C) 2000 Elsevier Science Inc.

本文言語英語
ページ(範囲)257-263
ページ数7
ジャーナルPeptides
21
2
DOI
出版ステータス出版済み - 2 2000

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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