TY - JOUR
T1 - Effects of adrenomedullin and PAMP on membrane potential and neurotransmission
AU - Goto, Kenichi
AU - Fujii, Koji
AU - Onaka, Uran
AU - Abe, Isao
AU - Fujishima, Masatoshi
N1 - Funding Information:
☆This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan (08670804), Tokyo, Japan.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000/2
Y1 - 2000/2
N2 - The effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) on membrane potential and sympathetic neurotransmission were studied in rat mesenteric arteries by using microelectrodes. AM (10-7 M) but not PAMP (10-6 M) produced membrane hyperpolarization, which was abolished by high K solution or by glibenclamide, an ATP-sensitive K+ (KATP) channel blocker. Neither AM nor PAMP affected excitatory junction potentials, a measure of sympathetic, purinergic neurotransmission. These findings suggest that AM hyperpolarizes the membrane via activation of KATP channels, which may contribute to the vasodilatory action of AM, whereas the mechanisms of the vasodepressor action of PAMP remain unclear. Copyright (C) 2000 Elsevier Science Inc.
AB - The effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) on membrane potential and sympathetic neurotransmission were studied in rat mesenteric arteries by using microelectrodes. AM (10-7 M) but not PAMP (10-6 M) produced membrane hyperpolarization, which was abolished by high K solution or by glibenclamide, an ATP-sensitive K+ (KATP) channel blocker. Neither AM nor PAMP affected excitatory junction potentials, a measure of sympathetic, purinergic neurotransmission. These findings suggest that AM hyperpolarizes the membrane via activation of KATP channels, which may contribute to the vasodilatory action of AM, whereas the mechanisms of the vasodepressor action of PAMP remain unclear. Copyright (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S0196-9781(99)00204-1
DO - 10.1016/S0196-9781(99)00204-1
M3 - Article
C2 - 10764954
AN - SCOPUS:0034032024
VL - 21
SP - 257
EP - 263
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 2
ER -