Effects of adrenomedullin and PAMP on membrane potential and neurotransmission

Kenichi Goto, Koji Fujii, Uran Onaka, Isao Abe, Masatoshi Fujishima

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

The effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) on membrane potential and sympathetic neurotransmission were studied in rat mesenteric arteries by using microelectrodes. AM (10-7 M) but not PAMP (10-6 M) produced membrane hyperpolarization, which was abolished by high K solution or by glibenclamide, an ATP-sensitive K+ (KATP) channel blocker. Neither AM nor PAMP affected excitatory junction potentials, a measure of sympathetic, purinergic neurotransmission. These findings suggest that AM hyperpolarizes the membrane via activation of KATP channels, which may contribute to the vasodilatory action of AM, whereas the mechanisms of the vasodepressor action of PAMP remain unclear. Copyright (C) 2000 Elsevier Science Inc.

元の言語英語
ページ(範囲)257-263
ページ数7
ジャーナルPeptides
21
発行部数2
DOI
出版物ステータス出版済み - 2 2000

Fingerprint

Adrenomedullin
Synaptic Transmission
Membrane Potentials
Membranes
KATP Channels
Mesenteric Arteries
Glyburide
Microelectrodes
Pathogen-Associated Molecular Pattern Molecules
Rats
Adenosine Triphosphate
Chemical activation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

これを引用

Effects of adrenomedullin and PAMP on membrane potential and neurotransmission. / Goto, Kenichi; Fujii, Koji; Onaka, Uran; Abe, Isao; Fujishima, Masatoshi.

:: Peptides, 巻 21, 番号 2, 02.2000, p. 257-263.

研究成果: ジャーナルへの寄稿記事

Goto, Kenichi ; Fujii, Koji ; Onaka, Uran ; Abe, Isao ; Fujishima, Masatoshi. / Effects of adrenomedullin and PAMP on membrane potential and neurotransmission. :: Peptides. 2000 ; 巻 21, 番号 2. pp. 257-263.
@article{178d85a760ce403a93b169fc85966217,
title = "Effects of adrenomedullin and PAMP on membrane potential and neurotransmission",
abstract = "The effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) on membrane potential and sympathetic neurotransmission were studied in rat mesenteric arteries by using microelectrodes. AM (10-7 M) but not PAMP (10-6 M) produced membrane hyperpolarization, which was abolished by high K solution or by glibenclamide, an ATP-sensitive K+ (KATP) channel blocker. Neither AM nor PAMP affected excitatory junction potentials, a measure of sympathetic, purinergic neurotransmission. These findings suggest that AM hyperpolarizes the membrane via activation of KATP channels, which may contribute to the vasodilatory action of AM, whereas the mechanisms of the vasodepressor action of PAMP remain unclear. Copyright (C) 2000 Elsevier Science Inc.",
author = "Kenichi Goto and Koji Fujii and Uran Onaka and Isao Abe and Masatoshi Fujishima",
year = "2000",
month = "2",
doi = "10.1016/S0196-9781(99)00204-1",
language = "English",
volume = "21",
pages = "257--263",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Effects of adrenomedullin and PAMP on membrane potential and neurotransmission

AU - Goto, Kenichi

AU - Fujii, Koji

AU - Onaka, Uran

AU - Abe, Isao

AU - Fujishima, Masatoshi

PY - 2000/2

Y1 - 2000/2

N2 - The effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) on membrane potential and sympathetic neurotransmission were studied in rat mesenteric arteries by using microelectrodes. AM (10-7 M) but not PAMP (10-6 M) produced membrane hyperpolarization, which was abolished by high K solution or by glibenclamide, an ATP-sensitive K+ (KATP) channel blocker. Neither AM nor PAMP affected excitatory junction potentials, a measure of sympathetic, purinergic neurotransmission. These findings suggest that AM hyperpolarizes the membrane via activation of KATP channels, which may contribute to the vasodilatory action of AM, whereas the mechanisms of the vasodepressor action of PAMP remain unclear. Copyright (C) 2000 Elsevier Science Inc.

AB - The effects of adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) on membrane potential and sympathetic neurotransmission were studied in rat mesenteric arteries by using microelectrodes. AM (10-7 M) but not PAMP (10-6 M) produced membrane hyperpolarization, which was abolished by high K solution or by glibenclamide, an ATP-sensitive K+ (KATP) channel blocker. Neither AM nor PAMP affected excitatory junction potentials, a measure of sympathetic, purinergic neurotransmission. These findings suggest that AM hyperpolarizes the membrane via activation of KATP channels, which may contribute to the vasodilatory action of AM, whereas the mechanisms of the vasodepressor action of PAMP remain unclear. Copyright (C) 2000 Elsevier Science Inc.

UR - http://www.scopus.com/inward/record.url?scp=0034032024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034032024&partnerID=8YFLogxK

U2 - 10.1016/S0196-9781(99)00204-1

DO - 10.1016/S0196-9781(99)00204-1

M3 - Article

C2 - 10764954

AN - SCOPUS:0034032024

VL - 21

SP - 257

EP - 263

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 2

ER -