Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats

Tatsuo Nakahara, Toshihide Kuroki, Hisao Hondo, Tetsuyuki Tsutsumi, Kenji Fukuda, Hiroshi Yao, Hideyuki Uchimura

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

Haloperidol augmented a trend of an increase in the heat shock protein (hsp70) mRNA levels induced by phencyclidine (PCP) in rat medial prefrontal cortex, nucleus accumbens and striatum, while the atypical antipsychotic drugs such as clozapine, olanzapine and risperidone decreased it. When administered alone, clozapine, but not haloperidol, decreased hsp70 mRNA levels. Haloperidol and the atypical antipsychotic drugs may thus have differential effects on hsp70 expression in some brain regions of PCP-treated rats.

元の言語英語
ページ(範囲)193-197
ページ数5
ジャーナルMolecular Brain Research
73
発行部数1-2
DOI
出版物ステータス出版済み - 11 10 1999
外部発表Yes

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Phencyclidine
Haloperidol
Heat-Shock Proteins
Antipsychotic Agents
Clozapine
olanzapine
Brain
Messenger RNA
Risperidone
Nucleus Accumbens
Prefrontal Cortex

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

これを引用

Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats. / Nakahara, Tatsuo; Kuroki, Toshihide; Hondo, Hisao; Tsutsumi, Tetsuyuki; Fukuda, Kenji; Yao, Hiroshi; Uchimura, Hideyuki.

:: Molecular Brain Research, 巻 73, 番号 1-2, 10.11.1999, p. 193-197.

研究成果: ジャーナルへの寄稿記事

Nakahara, Tatsuo ; Kuroki, Toshihide ; Hondo, Hisao ; Tsutsumi, Tetsuyuki ; Fukuda, Kenji ; Yao, Hiroshi ; Uchimura, Hideyuki. / Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats. :: Molecular Brain Research. 1999 ; 巻 73, 番号 1-2. pp. 193-197.
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