Effects of behavior therapy on regional cerebral blood flow in obsessive-compulsive disorder

Eriko Nakatani, Akiko Nakgawa, Yoko Ohara, Shoko Goto, Naruhiko Uozumi, Michiyo Iwakiri, Yukari Yamamoto, Keisuke Motomura, Yasuro Iikura, Toshiko Yamagami

研究成果: Contribution to journalArticle査読

89 被引用数 (Scopus)

抄録

Very few functional neuroimaging studies have been performed on patients with obsessive-compulsive disorder (OCD) undergoing behavior therapy, even though it is recognized to be an effective treatment for this disorder. We measured the regional cerebral blood flow (rCBF) using the Xenon inhalation method in 31 treatment-refractory patients with OCD and the same number of age-matched normal controls. We also studied changes in rCBF in 22 OCD patients who had demonstrated a significant improvement after the behavior therapy. The OCD patients showed a significant bilateral elevation in the rCBF in the basal ganglia compared with the normal controls. After successful treatment, a significant decrease was found in the rCBF in the right head of the caudate nucleus that tended to correlate with clinical improvement.

本文言語英語
ページ(範囲)113-120
ページ数8
ジャーナルPsychiatry Research - Neuroimaging
124
2
DOI
出版ステータス出版済み - 10 30 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(その他)
  • 放射線学、核医学およびイメージング
  • 精神医学および精神衛生

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