Effects of calcium antagonists nifedipine and flunarizine on phencyclidine-induced changes in the regional dopaminergic metabolism of the rat brain

K. Etou, T. Kuroki, Y. Tatebayashi, N. Tashiro, M. Hirano

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

To elucidate the psychotropic actions of calcium (Ca) antagonists, we investigated the effect of the voltage-dependent Ca channel antagonists, nifedipine and flunarizine, on phencyclidine (PCP)-induced changes in the monoamine metabolism in the regional brain areas of rats. The results indicate that the administration of nifedipine alone attenuated dopamine (DA) metabolism in the nucleus caudatus putamen while enhancing serotonin (5-HT) metabolism. By contrast, flunarizine increased DA metabolism. PCP significantly increased DA metabolite levels in the pre frontal cortex, the nucleus caudatus putamen, and the amygdala. The PCP-induced increases in DA metabolism in these regions were significantly antagonized by nifedipine, but not by flunarizine. These results indicate that nifedipine attenuates the PCP-induced hyperactivity of the dopaminergic neurons, suggesting antipsychotic properties for this drug.

本文言語英語
ページ(範囲)83-86
ページ数4
ジャーナルBiochemical Pharmacology
51
1
DOI
出版ステータス出版済み - 1 12 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

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