Effects of calcium antagonists nifedipine and flunarizine on phencyclidine-induced changes in the regional dopaminergic metabolism of the rat brain

K. Etou, T. Kuroki, Y. Tatebayashi, N. Tashiro, M. Hirano

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

To elucidate the psychotropic actions of calcium (Ca) antagonists, we investigated the effect of the voltage-dependent Ca channel antagonists, nifedipine and flunarizine, on phencyclidine (PCP)-induced changes in the monoamine metabolism in the regional brain areas of rats. The results indicate that the administration of nifedipine alone attenuated dopamine (DA) metabolism in the nucleus caudatus putamen while enhancing serotonin (5-HT) metabolism. By contrast, flunarizine increased DA metabolism. PCP significantly increased DA metabolite levels in the pre frontal cortex, the nucleus caudatus putamen, and the amygdala. The PCP-induced increases in DA metabolism in these regions were significantly antagonized by nifedipine, but not by flunarizine. These results indicate that nifedipine attenuates the PCP-induced hyperactivity of the dopaminergic neurons, suggesting antipsychotic properties for this drug.

元の言語英語
ページ(範囲)83-86
ページ数4
ジャーナルBiochemical Pharmacology
51
発行部数1
DOI
出版物ステータス出版済み - 1 12 1996

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Flunarizine
Phencyclidine
Nifedipine
Metabolism
Rats
Brain
Calcium
Dopamine
Caudate Nucleus
Putamen
Serotonin
Dopaminergic Neurons
Calcium Channel Blockers
Frontal Lobe
Calcium Channels
Metabolites
Amygdala
Antipsychotic Agents
Neurons

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

これを引用

Effects of calcium antagonists nifedipine and flunarizine on phencyclidine-induced changes in the regional dopaminergic metabolism of the rat brain. / Etou, K.; Kuroki, T.; Tatebayashi, Y.; Tashiro, N.; Hirano, M.

:: Biochemical Pharmacology, 巻 51, 番号 1, 12.01.1996, p. 83-86.

研究成果: ジャーナルへの寄稿記事

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AU - Hirano, M.

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N2 - To elucidate the psychotropic actions of calcium (Ca) antagonists, we investigated the effect of the voltage-dependent Ca channel antagonists, nifedipine and flunarizine, on phencyclidine (PCP)-induced changes in the monoamine metabolism in the regional brain areas of rats. The results indicate that the administration of nifedipine alone attenuated dopamine (DA) metabolism in the nucleus caudatus putamen while enhancing serotonin (5-HT) metabolism. By contrast, flunarizine increased DA metabolism. PCP significantly increased DA metabolite levels in the pre frontal cortex, the nucleus caudatus putamen, and the amygdala. The PCP-induced increases in DA metabolism in these regions were significantly antagonized by nifedipine, but not by flunarizine. These results indicate that nifedipine attenuates the PCP-induced hyperactivity of the dopaminergic neurons, suggesting antipsychotic properties for this drug.

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