Effects of Ca2+ antagonists and aminoglycoside antibiotics on Ca2+ current in isolated outer hair cells of guinea pig cochlea

T. Nakagawa, S. Kakehata, N. Akaike, S. Komune, T. Takasaka, T. Uemura

研究成果: Contribution to journalArticle査読

31 被引用数 (Scopus)

抄録

The effects of various Ca2+ antagonists and aminoglycoside antibiotics on the Ca2+ channel in isolated outer hair cells of the guinea pig were investigated using a whole-cell patch-clamp technique. The inhibitory action was in the order of La3+ ≫ Cd2+ ≫ Ni2+ ≫ Co2+ for inorganic Ca2+ antagonists, and flunarizine = nicardipine > ω-Conotoxin > methaxyverapamil = diltiazem ≫ amiloride for orgaini ones. Aminoglycoside antibiotics also had antagonistic effects on the Ca2+ channel.

本文言語英語
ページ(範囲)345-347
ページ数3
ジャーナルBrain Research
580
1-2
DOI
出版ステータス出版済み - 5 15 1992

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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