Effects of cold exposure and shear stress on endothelial nitric oxide synthase activation

Kamariah binti Md Isa, Naoto Kawasaki, Keiichi Ueyama, Tateki Sumii, Susumu Kudo

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

Endothelial nitric oxide synthase (eNOS) is the primary enzyme that produces nitric oxide (NO), which plays an important role in blood vessel relaxation. eNOS activation is stimulated by various mechanical forces, such as shear stress. Several studies have shown that local cooling of the human finger causes strong vasoconstriction, followed after several minutes by cold-induced vasodilation (CIVD). However, the role played by endothelial cells (ECs) in blood vessel regulation in respond to cold temperatures is not fully understood. In this study, we found that low temperature alone does not significantly increase or decrease eNOS activation in ECs. We further found that the combination of shear stress with temperature change leads to a significant increase in eNOS activation at 37 °C and 28 °C, and a decrease at 4 °C. These results show that ECs play an important role in blood vessel regulation under shear stress and low temperature.

本文言語英語
ページ(範囲)318-322
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
412
2
DOI
出版ステータス出版済み - 8 26 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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