Effects of conditioning intensity in allogeneic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia

Shuichiro Takashima, Toshihiro Miyamoto, Tomohiko Kamimura, Goichi Yoshimoto, Shuro Yoshida, Hideho Henzan, Ken Takase, Koji Kato, Yoshikiyo Ito, Yuju Ohno, Koji Nagafuji, Tetsuya Eto, Takanori Teshima, Koichi Akashi

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We retrospectively analyzed the outcomes of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) who underwent first allogeneic stem cell transplantation (allo-SCT) at complete remission (CR) with myeloablative conditioning (MAC, n = 31) or reduced-intensity conditioning (RIC, n = 15) between 2001 and 2012. All the patients had received tyrosine kinase inhibitor (TKI)-based chemotherapy prior to allo-SCT. Overall survival (OS) rates (57 vs 63 %, p = 0.53), leukemia-free survival rates (50 vs 65 %, p = 0.29), and non-relapse mortality rates (39 vs 35 %, p = 0.62) at 2 years were similar between the MAC and RIC groups. The minimal residual disease (MRD) status evaluated by sensitive polymerase chain reaction prior to allo-SCT did not influence the OS rate (77 vs 54 %, p = 0.28) and leukemia-free survival rate (69 vs 51 %, p = 0.48), irrespective of the conditioning intensity. Our data suggest that the RIC regimen may represent a sufficient intensity of therapeutic pre-transplant conditioning for patients with Ph+ALL who have maintained a hematological CR with TKI-combined chemotherapy.

元の言語英語
ページ(範囲)689-696
ページ数8
ジャーナルInternational journal of hematology
102
発行部数6
DOI
出版物ステータス出版済み - 12 1 2015

All Science Journal Classification (ASJC) codes

  • Hematology

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