Effects of Corynebacterium parvum on Escherichia coli infection in mice

Yasunobu Yoshikai, S. Miake, M. Mituyama, K. Nomoto

    研究成果: ジャーナルへの寄稿記事

    8 引用 (Scopus)

    抄録

    The contribution of activated macrophages to protection against E. coli was studied in mice. Mice treated intraperitoneally with killed C. parvum organisms 1 d prior to challenge showed an increased resistance to intraperitoneal infection with E. coli; the predominant leucocytes in the peritoneal cavity of these animals were polymorphonuclear cells. However, treatment with C. parvum 4d prior to challenge induced mainly activated macrophages in the peritoneal cavity and host resistance to the infection was not increased. Activated macrophages from such mice showed both enhanced phagocytic activity in vivo and a high degree of intracellular killing of E. coli in vitro. At the same time these cells became more susceptible to the cytotoxic effect of endotoxin. After challenge with E. coli there was a marked decrease in the number of peritoneal macrophages in mice that were treated with C. parvum 4d prior to challenge. Increased susceptibility of activated macrophages to the cytotoxic effect of endotoxin could explain the absence of enhanced resistance to E. coli infection in such animals.

    元の言語英語
    ページ(範囲)2857-2863
    ページ数7
    ジャーナルJournal of General Microbiology
    128
    発行部数12
    出版物ステータス出版済み - 12 1 1982

    Fingerprint

    Propionibacterium acnes
    Escherichia coli Infections
    Macrophages
    Peritoneal Cavity
    Escherichia coli
    Endotoxins
    Peritoneal Macrophages
    Leukocytes
    Infection

    All Science Journal Classification (ASJC) codes

    • Microbiology

    これを引用

    Yoshikai, Y., Miake, S., Mituyama, M., & Nomoto, K. (1982). Effects of Corynebacterium parvum on Escherichia coli infection in mice. Journal of General Microbiology, 128(12), 2857-2863.

    Effects of Corynebacterium parvum on Escherichia coli infection in mice. / Yoshikai, Yasunobu; Miake, S.; Mituyama, M.; Nomoto, K.

    :: Journal of General Microbiology, 巻 128, 番号 12, 01.12.1982, p. 2857-2863.

    研究成果: ジャーナルへの寄稿記事

    Yoshikai, Y, Miake, S, Mituyama, M & Nomoto, K 1982, 'Effects of Corynebacterium parvum on Escherichia coli infection in mice', Journal of General Microbiology, 巻. 128, 番号 12, pp. 2857-2863.
    Yoshikai Y, Miake S, Mituyama M, Nomoto K. Effects of Corynebacterium parvum on Escherichia coli infection in mice. Journal of General Microbiology. 1982 12 1;128(12):2857-2863.
    Yoshikai, Yasunobu ; Miake, S. ; Mituyama, M. ; Nomoto, K. / Effects of Corynebacterium parvum on Escherichia coli infection in mice. :: Journal of General Microbiology. 1982 ; 巻 128, 番号 12. pp. 2857-2863.
    @article{abcd410b5df54ac39e9d66cfd25a6a55,
    title = "Effects of Corynebacterium parvum on Escherichia coli infection in mice",
    abstract = "The contribution of activated macrophages to protection against E. coli was studied in mice. Mice treated intraperitoneally with killed C. parvum organisms 1 d prior to challenge showed an increased resistance to intraperitoneal infection with E. coli; the predominant leucocytes in the peritoneal cavity of these animals were polymorphonuclear cells. However, treatment with C. parvum 4d prior to challenge induced mainly activated macrophages in the peritoneal cavity and host resistance to the infection was not increased. Activated macrophages from such mice showed both enhanced phagocytic activity in vivo and a high degree of intracellular killing of E. coli in vitro. At the same time these cells became more susceptible to the cytotoxic effect of endotoxin. After challenge with E. coli there was a marked decrease in the number of peritoneal macrophages in mice that were treated with C. parvum 4d prior to challenge. Increased susceptibility of activated macrophages to the cytotoxic effect of endotoxin could explain the absence of enhanced resistance to E. coli infection in such animals.",
    author = "Yasunobu Yoshikai and S. Miake and M. Mituyama and K. Nomoto",
    year = "1982",
    month = "12",
    day = "1",
    language = "English",
    volume = "128",
    pages = "2857--2863",
    journal = "Microbiology",
    issn = "1350-0872",
    publisher = "Society for General Microbiology",
    number = "12",

    }

    TY - JOUR

    T1 - Effects of Corynebacterium parvum on Escherichia coli infection in mice

    AU - Yoshikai, Yasunobu

    AU - Miake, S.

    AU - Mituyama, M.

    AU - Nomoto, K.

    PY - 1982/12/1

    Y1 - 1982/12/1

    N2 - The contribution of activated macrophages to protection against E. coli was studied in mice. Mice treated intraperitoneally with killed C. parvum organisms 1 d prior to challenge showed an increased resistance to intraperitoneal infection with E. coli; the predominant leucocytes in the peritoneal cavity of these animals were polymorphonuclear cells. However, treatment with C. parvum 4d prior to challenge induced mainly activated macrophages in the peritoneal cavity and host resistance to the infection was not increased. Activated macrophages from such mice showed both enhanced phagocytic activity in vivo and a high degree of intracellular killing of E. coli in vitro. At the same time these cells became more susceptible to the cytotoxic effect of endotoxin. After challenge with E. coli there was a marked decrease in the number of peritoneal macrophages in mice that were treated with C. parvum 4d prior to challenge. Increased susceptibility of activated macrophages to the cytotoxic effect of endotoxin could explain the absence of enhanced resistance to E. coli infection in such animals.

    AB - The contribution of activated macrophages to protection against E. coli was studied in mice. Mice treated intraperitoneally with killed C. parvum organisms 1 d prior to challenge showed an increased resistance to intraperitoneal infection with E. coli; the predominant leucocytes in the peritoneal cavity of these animals were polymorphonuclear cells. However, treatment with C. parvum 4d prior to challenge induced mainly activated macrophages in the peritoneal cavity and host resistance to the infection was not increased. Activated macrophages from such mice showed both enhanced phagocytic activity in vivo and a high degree of intracellular killing of E. coli in vitro. At the same time these cells became more susceptible to the cytotoxic effect of endotoxin. After challenge with E. coli there was a marked decrease in the number of peritoneal macrophages in mice that were treated with C. parvum 4d prior to challenge. Increased susceptibility of activated macrophages to the cytotoxic effect of endotoxin could explain the absence of enhanced resistance to E. coli infection in such animals.

    UR - http://www.scopus.com/inward/record.url?scp=0020417384&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0020417384&partnerID=8YFLogxK

    M3 - Article

    C2 - 6763935

    AN - SCOPUS:0020417384

    VL - 128

    SP - 2857

    EP - 2863

    JO - Microbiology

    JF - Microbiology

    SN - 1350-0872

    IS - 12

    ER -