Effects of different dietary fats and proteins on cholesterol metabolism and eicosanoid production in hamsters

Marites Gatchalian-Yee, Misako Imamura, Michiko Nonaka, Jiongyan Gu, Michihiro Sugano

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

The present study was conducted to investigate the interaction of dietary protein, soybean protein (SOY) and casein (CAS); and fat, perilla oil (PER, α-linolenic acid) and safflower oil (SAF, linoleic acid), on cholesterol metabolism, liver fatty acid composition and splenic eicosanoid production in hamsters. Cholesterol-enriched diets (0.2%) containing 20% protein and 10% fat were given for 38 days. Neither hypocholesterolemic nor liver cholesterol-lowering effects of SOY in comparison to CAS were observed in this experiment. However, SOY stimulated fecal steroid excretion, particularly in combination with SAF. The fatty acid composition of liver phospholipids was in general not influenced by the type of dietary protein, but SOY interfered the conversion of 20:5n-3 to 22:6n-3 when fed with PER. Splenic production of leukotriene B4 was not influenced by dietary treatments whereas the production of PGE2 was significantly higher in hamsters fed SAF diets, particularly in combination with SOY. Thus, SOY in comparison to CAS has selective effects on various parameters of lipid metabolism when added in cholesterol-enriched diets.

元の言語英語
ページ(範囲)1149-1158
ページ数10
ジャーナルNutrition Research
15
発行部数8
DOI
出版物ステータス出版済み - 1 1 1995

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Soybean Proteins
Dietary Proteins
Eicosanoids
Dietary Fats
Cricetinae
Cholesterol
Caseins
Diet
Liver
Fatty Acids
Fats
Safflower Oil
Leukotriene B4
alpha-Linolenic Acid
Linoleic Acid
Lipid Metabolism
Dinoprostone
Phospholipids
Steroids
Syntex adjuvant formulation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

これを引用

Effects of different dietary fats and proteins on cholesterol metabolism and eicosanoid production in hamsters. / Gatchalian-Yee, Marites; Imamura, Misako; Nonaka, Michiko; Gu, Jiongyan; Sugano, Michihiro.

:: Nutrition Research, 巻 15, 番号 8, 01.01.1995, p. 1149-1158.

研究成果: ジャーナルへの寄稿記事

Gatchalian-Yee, Marites ; Imamura, Misako ; Nonaka, Michiko ; Gu, Jiongyan ; Sugano, Michihiro. / Effects of different dietary fats and proteins on cholesterol metabolism and eicosanoid production in hamsters. :: Nutrition Research. 1995 ; 巻 15, 番号 8. pp. 1149-1158.
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