Effects of isolated compound from Sonneratia caseolaris leaf: A validation of traditional utilization by melanin biosynthesis and antioxidant assays

Enos Tangke Arung, Harlinda Kuspradini, Irawan Wijaya Kusuma, Tran Hai Bang, Shuntaro Yamashita, Yoshinori Katakura, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

In continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O-?-glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O-?-glucoside showed the inhibitory activity in a dose-dependent manner and reach 44% of inhibition at 223.2 μM with 92% of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.

元の言語英語
ページ(範囲)39-43
ページ数5
ジャーナルJournal of Applied Pharmaceutical Science
5
発行部数10
DOI
出版物ステータス出版済み - 1 1 2015

Fingerprint

Melanins
Population Groups
Skin Care
Luteolin
Antioxidants
Glucosides
Skin Lightening Preparations
Experimental Melanomas
Indonesia
Cell Survival
Oxidative Stress
Ethanol
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

これを引用

Effects of isolated compound from Sonneratia caseolaris leaf : A validation of traditional utilization by melanin biosynthesis and antioxidant assays. / Arung, Enos Tangke; Kuspradini, Harlinda; Kusuma, Irawan Wijaya; Bang, Tran Hai; Yamashita, Shuntaro; Katakura, Yoshinori; Shimizu, Kuniyoshi.

:: Journal of Applied Pharmaceutical Science, 巻 5, 番号 10, 01.01.2015, p. 39-43.

研究成果: ジャーナルへの寄稿記事

@article{43eb279beb2641719124064b8402c787,
title = "Effects of isolated compound from Sonneratia caseolaris leaf: A validation of traditional utilization by melanin biosynthesis and antioxidant assays",
abstract = "In continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O-?-glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O-?-glucoside showed the inhibitory activity in a dose-dependent manner and reach 44{\%} of inhibition at 223.2 μM with 92{\%} of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.",
author = "Arung, {Enos Tangke} and Harlinda Kuspradini and Kusuma, {Irawan Wijaya} and Bang, {Tran Hai} and Shuntaro Yamashita and Yoshinori Katakura and Kuniyoshi Shimizu",
year = "2015",
month = "1",
day = "1",
doi = "10.7324/JAPS.2015.501007",
language = "English",
volume = "5",
pages = "39--43",
journal = "Journal of Applied Pharmaceutical Science",
issn = "2231-3354",
publisher = "MediPoeia",
number = "10",

}

TY - JOUR

T1 - Effects of isolated compound from Sonneratia caseolaris leaf

T2 - A validation of traditional utilization by melanin biosynthesis and antioxidant assays

AU - Arung, Enos Tangke

AU - Kuspradini, Harlinda

AU - Kusuma, Irawan Wijaya

AU - Bang, Tran Hai

AU - Yamashita, Shuntaro

AU - Katakura, Yoshinori

AU - Shimizu, Kuniyoshi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - In continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O-?-glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O-?-glucoside showed the inhibitory activity in a dose-dependent manner and reach 44% of inhibition at 223.2 μM with 92% of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.

AB - In continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O-?-glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O-?-glucoside showed the inhibitory activity in a dose-dependent manner and reach 44% of inhibition at 223.2 μM with 92% of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.

UR - http://www.scopus.com/inward/record.url?scp=84946028069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946028069&partnerID=8YFLogxK

U2 - 10.7324/JAPS.2015.501007

DO - 10.7324/JAPS.2015.501007

M3 - Article

AN - SCOPUS:84946028069

VL - 5

SP - 39

EP - 43

JO - Journal of Applied Pharmaceutical Science

JF - Journal of Applied Pharmaceutical Science

SN - 2231-3354

IS - 10

ER -