Effects of lipid composition on entrapment of proteins into phosphatidylglycerol-containing liposomes

Sunao Murakami, Tetsuya Fujita, Tsutomu Ono, Shinji Sakai, Hiroyuki Ijima, Koei Kawakami

研究成果: Contribution to journalArticle査読

抄録

Liposomes composed of phosphatidylcholine (PC) and phosphatidylglycerol (PG) were prepared to examine the effects of lipid composition on surface properties of the liposomes and entrapment efficiency of proteins into the liposomes. Lipid composition was found to influence the amount and mode of proteins entrapped into the PC/PG liposomes, as well as the surface properties of the liposomes. Both electrostatic and non-electrostatic interactions between protein and liposome played important roles in the entrapment of protein into the PC-containing liposomes, and the amount of proteins adsorbed electrostatically on the PG-containing liposomes was also influenced by lipid composition.

本文言語英語
ページ(範囲)514-517
ページ数4
ジャーナルkagaku kogaku ronbunshu
32
6
DOI
出版ステータス出版済み - 2006

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 化学工学(全般)

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