Effects of mechanical stress and scaffold material on osteogenesis and chondrogenesis

O. Suzuki, I. Takahashi, S. Kamakura, K. Sasaki, R. Kamijo, M. Nakamura, M. Oda, T. Uchida, F. Arai, T. Fukuda

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

4 被引用数 (Scopus)

抄録

The present study was designed to investigate how mouse bone marrow stromal ST2 cells and rat limb mesenchymal stem cells respond to mechanical stress. Mechanical stress loading culture devices originally developed or commercially available were used to induce quantitative strain to these cells. Differentiation of ST2, estimated by alkaline phosphatase (ALP), was shown to be affected by the amount of the strain. Chondrogenic cell differentiation was enhanced by stretch stimulation through phosphplylation of extracellular- signaling regulated kinases (ERKs). In this study, effect of synthetic scaffold octacalcium phosphate (OCP) was also determined. OCP implantation enhanced bone regeneration. The results suggest that the differentiation of these skeletal tissue forming cells is under control of the mechanical stresses through the signaling cascade. It is likely that the scaffold plays a role of site scaffolding the cells to assist differentiation.

本文言語英語
ホスト出版物のタイトルProceedings of the 2005 International Symposium on Micro-NanoMechatronics and Human Science, Eighth Symposium on Micro- and Nano-Mechatronics for Information-Based Society - The 21st Century COE Progr
ページ235-240
ページ数6
DOI
出版ステータス出版済み - 2005
外部発表はい
イベント2005 International Symposium on Micro-NanoMechatronics and Human Science, Eighth Symposium on Micro- and Nano-Mechatronics for Information-Based Society - The 21st Century COE Program - Nagayo, 日本
継続期間: 11 7 200511 9 2005

出版物シリーズ

名前Proceedings of the 2005 International Symposium on Micro-NanoMechatronics and Human Science, Eighth Symposium on Micro- and Nano-Mechatronics for Information-Based Society - The 21st Century COE Progr
2005

その他

その他2005 International Symposium on Micro-NanoMechatronics and Human Science, Eighth Symposium on Micro- and Nano-Mechatronics for Information-Based Society - The 21st Century COE Program
国/地域日本
CityNagayo
Period11/7/0511/9/05

All Science Journal Classification (ASJC) codes

  • 工学(全般)

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