Effects of menstrual cycle on background parenchymal enhancement and detectability of breast cancer on dynamic contrast-enhanced breast MRI

A multicenter study of an Asian population

Takeshi Kamitani, Hidetake Yabuuchi, Yoshihide Kanemaki, Mitsuhiro Tozaki, Tetsuo Sonomura, Waka Mizukoshi, Waka Nakata, Taro Shimono, Misugi Urano, Toshiko Yamano, Fumi Kato, Megumi Kuchiki, Nobuyuki Shiragami, Hisami Yanagita, Eisuke Katsuda, Masako Kataoka, Ken Yamaguchi, Takuro Horikoshi, Tatsuya Gomi, Miwako Nozaki & 9 others Motoi Shiotani, Maki Amano, Hirokazu Saigusa, Shunichi Sadaoka, Hisashi Kamiya, Makoto Kubo, Nami Yamashita, Hidetaka Yamamoto, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

抄録

Purpose: To evaluate the effect of the menstrual cycle on BPE and cancer detectability in an Asian population. Material and methods: 266 premenopausal patients with regular menstrual cycles from 24 centers were included, and 176 of them were diagnosed by pathology as having breast cancer. Thirty-five patients were examined in the menstrual phase (days 1–4), 105 in the proliferative phase (days 5–14), and 126 in the secretory phase (days 15–30). Measurement of the following signal intensities (SIs) were obtained: breast tissue on the unaffected side on a pre-contrast image (SI1) and an early-phase image (SI2); the SIs of breast tissue on the affected side on a pre-contrast image (SI3) and an early-phase image (SI4); and the SIs of breast cancer on a pre-contrast image (SI5) and an early-phase image (SI6). We calculated the BPE ratio, i.e., (SI2– SI1)/SI1 and the cancer/background enhancement ratio (C/B) ratio, i.e., (SI6– SI5) / (SI4– SI3). The BPE was classified as minimal, mild, moderate, or marked, and the cancer detectability was classified as excellent, good, or poor independently by two radiologists. Results: The average C/B ratio was 20.1, 15.7, and 9.1 at the menstrual, proliferative, and secretory phases (p < 0.001). BPE was determined as moderate or marked in 0% and 5.4% at the menstrual phase, 10.3% and 11.0% at the proliferative phase, and 17.5% and 21.7% at the secretory phase by the two observers, respectively (p = 0.01, p = 0.01). The detectability of breast cancer was classified as poor in 0% and 0%, 1.4% and 13.0%, and 8.0% and 22.1% at the menstrual, proliferative, and secretory phases by the two observers, respectively (p = 0.07, p = 0.02). Conclusion: The menstrual phase and the proliferative phase seem to be suitable for breast MRI of Asian women.

元の言語英語
ページ(範囲)130-135
ページ数6
ジャーナルEuropean Journal of Radiology
110
DOI
出版物ステータス出版済み - 1 1 2019

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Menstrual Cycle
Multicenter Studies
Follicular Phase
Breast
Breast Neoplasms
Luteal Phase
Population
Neoplasms
Pathology

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

Effects of menstrual cycle on background parenchymal enhancement and detectability of breast cancer on dynamic contrast-enhanced breast MRI : A multicenter study of an Asian population. / Kamitani, Takeshi; Yabuuchi, Hidetake; Kanemaki, Yoshihide; Tozaki, Mitsuhiro; Sonomura, Tetsuo; Mizukoshi, Waka; Nakata, Waka; Shimono, Taro; Urano, Misugi; Yamano, Toshiko; Kato, Fumi; Kuchiki, Megumi; Shiragami, Nobuyuki; Yanagita, Hisami; Katsuda, Eisuke; Kataoka, Masako; Yamaguchi, Ken; Horikoshi, Takuro; Gomi, Tatsuya; Nozaki, Miwako; Shiotani, Motoi; Amano, Maki; Saigusa, Hirokazu; Sadaoka, Shunichi; Kamiya, Hisashi; Kubo, Makoto; Yamashita, Nami; Yamamoto, Hidetaka; Honda, Hiroshi.

:: European Journal of Radiology, 巻 110, 01.01.2019, p. 130-135.

研究成果: ジャーナルへの寄稿記事

Kamitani, T, Yabuuchi, H, Kanemaki, Y, Tozaki, M, Sonomura, T, Mizukoshi, W, Nakata, W, Shimono, T, Urano, M, Yamano, T, Kato, F, Kuchiki, M, Shiragami, N, Yanagita, H, Katsuda, E, Kataoka, M, Yamaguchi, K, Horikoshi, T, Gomi, T, Nozaki, M, Shiotani, M, Amano, M, Saigusa, H, Sadaoka, S, Kamiya, H, Kubo, M, Yamashita, N, Yamamoto, H & Honda, H 2019, 'Effects of menstrual cycle on background parenchymal enhancement and detectability of breast cancer on dynamic contrast-enhanced breast MRI: A multicenter study of an Asian population', European Journal of Radiology, 巻. 110, pp. 130-135. https://doi.org/10.1016/j.ejrad.2018.11.025
Kamitani, Takeshi ; Yabuuchi, Hidetake ; Kanemaki, Yoshihide ; Tozaki, Mitsuhiro ; Sonomura, Tetsuo ; Mizukoshi, Waka ; Nakata, Waka ; Shimono, Taro ; Urano, Misugi ; Yamano, Toshiko ; Kato, Fumi ; Kuchiki, Megumi ; Shiragami, Nobuyuki ; Yanagita, Hisami ; Katsuda, Eisuke ; Kataoka, Masako ; Yamaguchi, Ken ; Horikoshi, Takuro ; Gomi, Tatsuya ; Nozaki, Miwako ; Shiotani, Motoi ; Amano, Maki ; Saigusa, Hirokazu ; Sadaoka, Shunichi ; Kamiya, Hisashi ; Kubo, Makoto ; Yamashita, Nami ; Yamamoto, Hidetaka ; Honda, Hiroshi. / Effects of menstrual cycle on background parenchymal enhancement and detectability of breast cancer on dynamic contrast-enhanced breast MRI : A multicenter study of an Asian population. :: European Journal of Radiology. 2019 ; 巻 110. pp. 130-135.
@article{1626e1dd5fde49bd9ea19df0cbd37fd9,
title = "Effects of menstrual cycle on background parenchymal enhancement and detectability of breast cancer on dynamic contrast-enhanced breast MRI: A multicenter study of an Asian population",
abstract = "Purpose: To evaluate the effect of the menstrual cycle on BPE and cancer detectability in an Asian population. Material and methods: 266 premenopausal patients with regular menstrual cycles from 24 centers were included, and 176 of them were diagnosed by pathology as having breast cancer. Thirty-five patients were examined in the menstrual phase (days 1–4), 105 in the proliferative phase (days 5–14), and 126 in the secretory phase (days 15–30). Measurement of the following signal intensities (SIs) were obtained: breast tissue on the unaffected side on a pre-contrast image (SI1) and an early-phase image (SI2); the SIs of breast tissue on the affected side on a pre-contrast image (SI3) and an early-phase image (SI4); and the SIs of breast cancer on a pre-contrast image (SI5) and an early-phase image (SI6). We calculated the BPE ratio, i.e., (SI2– SI1)/SI1 and the cancer/background enhancement ratio (C/B) ratio, i.e., (SI6– SI5) / (SI4– SI3). The BPE was classified as minimal, mild, moderate, or marked, and the cancer detectability was classified as excellent, good, or poor independently by two radiologists. Results: The average C/B ratio was 20.1, 15.7, and 9.1 at the menstrual, proliferative, and secretory phases (p < 0.001). BPE was determined as moderate or marked in 0{\%} and 5.4{\%} at the menstrual phase, 10.3{\%} and 11.0{\%} at the proliferative phase, and 17.5{\%} and 21.7{\%} at the secretory phase by the two observers, respectively (p = 0.01, p = 0.01). The detectability of breast cancer was classified as poor in 0{\%} and 0{\%}, 1.4{\%} and 13.0{\%}, and 8.0{\%} and 22.1{\%} at the menstrual, proliferative, and secretory phases by the two observers, respectively (p = 0.07, p = 0.02). Conclusion: The menstrual phase and the proliferative phase seem to be suitable for breast MRI of Asian women.",
author = "Takeshi Kamitani and Hidetake Yabuuchi and Yoshihide Kanemaki and Mitsuhiro Tozaki and Tetsuo Sonomura and Waka Mizukoshi and Waka Nakata and Taro Shimono and Misugi Urano and Toshiko Yamano and Fumi Kato and Megumi Kuchiki and Nobuyuki Shiragami and Hisami Yanagita and Eisuke Katsuda and Masako Kataoka and Ken Yamaguchi and Takuro Horikoshi and Tatsuya Gomi and Miwako Nozaki and Motoi Shiotani and Maki Amano and Hirokazu Saigusa and Shunichi Sadaoka and Hisashi Kamiya and Makoto Kubo and Nami Yamashita and Hidetaka Yamamoto and Hiroshi Honda",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.ejrad.2018.11.025",
language = "English",
volume = "110",
pages = "130--135",
journal = "European Journal of Radiology",
issn = "0720-048X",

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TY - JOUR

T1 - Effects of menstrual cycle on background parenchymal enhancement and detectability of breast cancer on dynamic contrast-enhanced breast MRI

T2 - A multicenter study of an Asian population

AU - Kamitani, Takeshi

AU - Yabuuchi, Hidetake

AU - Kanemaki, Yoshihide

AU - Tozaki, Mitsuhiro

AU - Sonomura, Tetsuo

AU - Mizukoshi, Waka

AU - Nakata, Waka

AU - Shimono, Taro

AU - Urano, Misugi

AU - Yamano, Toshiko

AU - Kato, Fumi

AU - Kuchiki, Megumi

AU - Shiragami, Nobuyuki

AU - Yanagita, Hisami

AU - Katsuda, Eisuke

AU - Kataoka, Masako

AU - Yamaguchi, Ken

AU - Horikoshi, Takuro

AU - Gomi, Tatsuya

AU - Nozaki, Miwako

AU - Shiotani, Motoi

AU - Amano, Maki

AU - Saigusa, Hirokazu

AU - Sadaoka, Shunichi

AU - Kamiya, Hisashi

AU - Kubo, Makoto

AU - Yamashita, Nami

AU - Yamamoto, Hidetaka

AU - Honda, Hiroshi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To evaluate the effect of the menstrual cycle on BPE and cancer detectability in an Asian population. Material and methods: 266 premenopausal patients with regular menstrual cycles from 24 centers were included, and 176 of them were diagnosed by pathology as having breast cancer. Thirty-five patients were examined in the menstrual phase (days 1–4), 105 in the proliferative phase (days 5–14), and 126 in the secretory phase (days 15–30). Measurement of the following signal intensities (SIs) were obtained: breast tissue on the unaffected side on a pre-contrast image (SI1) and an early-phase image (SI2); the SIs of breast tissue on the affected side on a pre-contrast image (SI3) and an early-phase image (SI4); and the SIs of breast cancer on a pre-contrast image (SI5) and an early-phase image (SI6). We calculated the BPE ratio, i.e., (SI2– SI1)/SI1 and the cancer/background enhancement ratio (C/B) ratio, i.e., (SI6– SI5) / (SI4– SI3). The BPE was classified as minimal, mild, moderate, or marked, and the cancer detectability was classified as excellent, good, or poor independently by two radiologists. Results: The average C/B ratio was 20.1, 15.7, and 9.1 at the menstrual, proliferative, and secretory phases (p < 0.001). BPE was determined as moderate or marked in 0% and 5.4% at the menstrual phase, 10.3% and 11.0% at the proliferative phase, and 17.5% and 21.7% at the secretory phase by the two observers, respectively (p = 0.01, p = 0.01). The detectability of breast cancer was classified as poor in 0% and 0%, 1.4% and 13.0%, and 8.0% and 22.1% at the menstrual, proliferative, and secretory phases by the two observers, respectively (p = 0.07, p = 0.02). Conclusion: The menstrual phase and the proliferative phase seem to be suitable for breast MRI of Asian women.

AB - Purpose: To evaluate the effect of the menstrual cycle on BPE and cancer detectability in an Asian population. Material and methods: 266 premenopausal patients with regular menstrual cycles from 24 centers were included, and 176 of them were diagnosed by pathology as having breast cancer. Thirty-five patients were examined in the menstrual phase (days 1–4), 105 in the proliferative phase (days 5–14), and 126 in the secretory phase (days 15–30). Measurement of the following signal intensities (SIs) were obtained: breast tissue on the unaffected side on a pre-contrast image (SI1) and an early-phase image (SI2); the SIs of breast tissue on the affected side on a pre-contrast image (SI3) and an early-phase image (SI4); and the SIs of breast cancer on a pre-contrast image (SI5) and an early-phase image (SI6). We calculated the BPE ratio, i.e., (SI2– SI1)/SI1 and the cancer/background enhancement ratio (C/B) ratio, i.e., (SI6– SI5) / (SI4– SI3). The BPE was classified as minimal, mild, moderate, or marked, and the cancer detectability was classified as excellent, good, or poor independently by two radiologists. Results: The average C/B ratio was 20.1, 15.7, and 9.1 at the menstrual, proliferative, and secretory phases (p < 0.001). BPE was determined as moderate or marked in 0% and 5.4% at the menstrual phase, 10.3% and 11.0% at the proliferative phase, and 17.5% and 21.7% at the secretory phase by the two observers, respectively (p = 0.01, p = 0.01). The detectability of breast cancer was classified as poor in 0% and 0%, 1.4% and 13.0%, and 8.0% and 22.1% at the menstrual, proliferative, and secretory phases by the two observers, respectively (p = 0.07, p = 0.02). Conclusion: The menstrual phase and the proliferative phase seem to be suitable for breast MRI of Asian women.

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JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

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