Effects of nicorandil on electromechanical activity of frog atrial muscle

Mami Noda, Ikunobu Muramatsu

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

The effects of the antianginal drug nicorandil on electrical and mechanical activity of bullfrog atria were examined. The application of nicorandil at concentrations from 0.3 to 10m M caused a negative inotropic effect without any appreciable change in the resting membrane potential. The amplitude of action potentials was attenuated. In the voltage clamp experiments, the slow inward current was slightly inhibited, but the background inward current and delayed outward current were not affected in the presence of nicorandil. The inward rectifying properties of time-independent outward current were slightly inhibited by 10m M nicorandil. Nicorandil inhibited the caffeine-induced contractures elicited in the depolarized preparation, but had no effect on the contracture mediated through the Na-Ca exchange mechanism. These results suggest that the negative inotropic action of nicorandil is caused by inhibition of Ca influx and intracellular mobilization of Ca. Nicorandil had little effect on the potassium conductance in this preparation.

本文言語英語
ページ(範囲)237-241
ページ数5
ジャーナルJournal of Cardiovascular Pharmacology
9
2
DOI
出版ステータス出版済み - 1 1 1987
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 循環器および心血管医学

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