抄録
There are no reports in the literature regarding the effect of pentazocine (PENT) on autonomic responses to surgical stimulation. Therefore, we examined the effects of intravenously administered (iv) PENT, either before or after the skin incision, on the cardiovascular and plasma catecholamine responses, as characterized by plasma levels of epinephrine (Epi) and norepinephrine (Nor), to surgical noxious stimulation of patients. Hemodynamic and sympathoadrenergic reactions occurred after the skin incision had been made, and iv PENT (0.6 mg/kg) before the incision attenuated both cardiovascular and sympatho-adrenal responses to surgical stimulation compared with those after the skin incision under isoflurane-nitrous oxide anesthesia. The attenuation of these responses to surgical stimulation was greater at 0.6 mg/kg than at 1.2 mg/kg. Our present data suggest that it might be difficult for iv PENT to block the activated sympathetic outflows once the sympathetic nervous system has been activated by surgically noxious stimulation. According to our present results, iv PENT (0.6 mg/kg, but not 1.2 mg/kg) before a skin incision seems to be of clinical relevance for attenuation of the hemodynamic response to surgical stimulation although the effects of PENT on the autonomic nervous system appears to be complex and difficult to interpret.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 35-40 |
| ページ数 | 6 |
| ジャーナル | Anesthesia and Resuscitation |
| 巻 | 47 |
| 発行部数 | 1 |
| 出版物ステータス | 出版済み - 3 1 2011 |
| 外部発表 | Yes |
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All Science Journal Classification (ASJC) codes
- Emergency Medicine
- Anesthesiology and Pain Medicine
これを引用
Effects of pentazocine on cardiovascular and plasma catecholamine responses in surgical patients. / Onuki, Noriko; Oyake, Hiroshi; Onuki, Kazuyuki; Tsukamoto, Masanori; Hori, Kouichirou; Nagasaka, Hiroshi.
：: Anesthesia and Resuscitation, 巻 47, 番号 1, 01.03.2011, p. 35-40.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Effects of pentazocine on cardiovascular and plasma catecholamine responses in surgical patients
AU - Onuki, Noriko
AU - Oyake, Hiroshi
AU - Onuki, Kazuyuki
AU - Tsukamoto, Masanori
AU - Hori, Kouichirou
AU - Nagasaka, Hiroshi
PY - 2011/3/1
Y1 - 2011/3/1
N2 - There are no reports in the literature regarding the effect of pentazocine (PENT) on autonomic responses to surgical stimulation. Therefore, we examined the effects of intravenously administered (iv) PENT, either before or after the skin incision, on the cardiovascular and plasma catecholamine responses, as characterized by plasma levels of epinephrine (Epi) and norepinephrine (Nor), to surgical noxious stimulation of patients. Hemodynamic and sympathoadrenergic reactions occurred after the skin incision had been made, and iv PENT (0.6 mg/kg) before the incision attenuated both cardiovascular and sympatho-adrenal responses to surgical stimulation compared with those after the skin incision under isoflurane-nitrous oxide anesthesia. The attenuation of these responses to surgical stimulation was greater at 0.6 mg/kg than at 1.2 mg/kg. Our present data suggest that it might be difficult for iv PENT to block the activated sympathetic outflows once the sympathetic nervous system has been activated by surgically noxious stimulation. According to our present results, iv PENT (0.6 mg/kg, but not 1.2 mg/kg) before a skin incision seems to be of clinical relevance for attenuation of the hemodynamic response to surgical stimulation although the effects of PENT on the autonomic nervous system appears to be complex and difficult to interpret.
AB - There are no reports in the literature regarding the effect of pentazocine (PENT) on autonomic responses to surgical stimulation. Therefore, we examined the effects of intravenously administered (iv) PENT, either before or after the skin incision, on the cardiovascular and plasma catecholamine responses, as characterized by plasma levels of epinephrine (Epi) and norepinephrine (Nor), to surgical noxious stimulation of patients. Hemodynamic and sympathoadrenergic reactions occurred after the skin incision had been made, and iv PENT (0.6 mg/kg) before the incision attenuated both cardiovascular and sympatho-adrenal responses to surgical stimulation compared with those after the skin incision under isoflurane-nitrous oxide anesthesia. The attenuation of these responses to surgical stimulation was greater at 0.6 mg/kg than at 1.2 mg/kg. Our present data suggest that it might be difficult for iv PENT to block the activated sympathetic outflows once the sympathetic nervous system has been activated by surgically noxious stimulation. According to our present results, iv PENT (0.6 mg/kg, but not 1.2 mg/kg) before a skin incision seems to be of clinical relevance for attenuation of the hemodynamic response to surgical stimulation although the effects of PENT on the autonomic nervous system appears to be complex and difficult to interpret.
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M3 - Article
VL - 47
SP - 35
EP - 40
JO - Hiroshima Journal of Anesthesia
JF - Hiroshima Journal of Anesthesia
SN - 0385-1664
IS - 1
ER -