Effects of rooibos (aspalathus linearis) extract on dryness of mouth, eye and skin in human

A randomized, double-blind, placebo-controlled study

Takao Iwai, Saori Nishimachi, Noriyuki Monoi, Akira Uchiyama, Seiji Nakamura

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Objective We investigated effects of food containing rooibos (Aspalathus linearis) extract including eriodictyol-6-Oglucoside (E6CG) on dryness of mouth, eye, and skin in human in a randomized, double-blind, placebo-controlled, crossover trial. Methods Thirty healthy adults with subjective dryness of multiple parts in mouth, eye, and skin were randomly devided into 2 groups and then instructed to intake either 100 mg of rooibos extract (0.21 mg of E6CG) or placebo for 2 weeks, respectively. The subjective dryness indices using the visual analog scale and the objective indices based on saliva flow rate, tear volume, and stratum corneum moisture content were evaluated before and after intake of the foods. This study was registered with UMIN Clinical Trials Registry as UMIN 000029492. Results Rooibos extract intake significantly improved the subjective dryness of mouth (P= 0.019), eye (P=0.006) and skin (P=0.030) and the objective indices of saliva flow rate (P= 0.045), tear volume (P=0.012) and stratum corneum moisture content (P=0.004). Conclusions This clinical study demonstrated that rooibos extract intake improves dryness of mouth, eye and skin.

元の言語英語
ページ(範囲)997-1003
ページ数7
ジャーナルJapanese Pharmacology and Therapeutics
46
発行部数6
出版物ステータス出版済み - 1 1 2018

Fingerprint

Aspalathus
Xerostomia
Placebos
Skin
Tears
Saliva
Cornea
Visual Analog Scale
Cross-Over Studies
Registries
Mouth
Eating
Clinical Trials
Food

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

これを引用

Effects of rooibos (aspalathus linearis) extract on dryness of mouth, eye and skin in human : A randomized, double-blind, placebo-controlled study. / Iwai, Takao; Nishimachi, Saori; Monoi, Noriyuki; Uchiyama, Akira; Nakamura, Seiji.

:: Japanese Pharmacology and Therapeutics, 巻 46, 番号 6, 01.01.2018, p. 997-1003.

研究成果: ジャーナルへの寄稿記事

@article{64e59058fafb4544992a40ec2ca7b92e,
title = "Effects of rooibos (aspalathus linearis) extract on dryness of mouth, eye and skin in human: A randomized, double-blind, placebo-controlled study",
abstract = "Objective We investigated effects of food containing rooibos (Aspalathus linearis) extract including eriodictyol-6-Oglucoside (E6CG) on dryness of mouth, eye, and skin in human in a randomized, double-blind, placebo-controlled, crossover trial. Methods Thirty healthy adults with subjective dryness of multiple parts in mouth, eye, and skin were randomly devided into 2 groups and then instructed to intake either 100 mg of rooibos extract (0.21 mg of E6CG) or placebo for 2 weeks, respectively. The subjective dryness indices using the visual analog scale and the objective indices based on saliva flow rate, tear volume, and stratum corneum moisture content were evaluated before and after intake of the foods. This study was registered with UMIN Clinical Trials Registry as UMIN 000029492. Results Rooibos extract intake significantly improved the subjective dryness of mouth (P= 0.019), eye (P=0.006) and skin (P=0.030) and the objective indices of saliva flow rate (P= 0.045), tear volume (P=0.012) and stratum corneum moisture content (P=0.004). Conclusions This clinical study demonstrated that rooibos extract intake improves dryness of mouth, eye and skin.",
author = "Takao Iwai and Saori Nishimachi and Noriyuki Monoi and Akira Uchiyama and Seiji Nakamura",
year = "2018",
month = "1",
day = "1",
language = "English",
volume = "46",
pages = "997--1003",
journal = "Japanese Pharmacology and Therapeutics",
issn = "0386-3603",
publisher = "Life Science Publishing Co. Ltd",
number = "6",

}

TY - JOUR

T1 - Effects of rooibos (aspalathus linearis) extract on dryness of mouth, eye and skin in human

T2 - A randomized, double-blind, placebo-controlled study

AU - Iwai, Takao

AU - Nishimachi, Saori

AU - Monoi, Noriyuki

AU - Uchiyama, Akira

AU - Nakamura, Seiji

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective We investigated effects of food containing rooibos (Aspalathus linearis) extract including eriodictyol-6-Oglucoside (E6CG) on dryness of mouth, eye, and skin in human in a randomized, double-blind, placebo-controlled, crossover trial. Methods Thirty healthy adults with subjective dryness of multiple parts in mouth, eye, and skin were randomly devided into 2 groups and then instructed to intake either 100 mg of rooibos extract (0.21 mg of E6CG) or placebo for 2 weeks, respectively. The subjective dryness indices using the visual analog scale and the objective indices based on saliva flow rate, tear volume, and stratum corneum moisture content were evaluated before and after intake of the foods. This study was registered with UMIN Clinical Trials Registry as UMIN 000029492. Results Rooibos extract intake significantly improved the subjective dryness of mouth (P= 0.019), eye (P=0.006) and skin (P=0.030) and the objective indices of saliva flow rate (P= 0.045), tear volume (P=0.012) and stratum corneum moisture content (P=0.004). Conclusions This clinical study demonstrated that rooibos extract intake improves dryness of mouth, eye and skin.

AB - Objective We investigated effects of food containing rooibos (Aspalathus linearis) extract including eriodictyol-6-Oglucoside (E6CG) on dryness of mouth, eye, and skin in human in a randomized, double-blind, placebo-controlled, crossover trial. Methods Thirty healthy adults with subjective dryness of multiple parts in mouth, eye, and skin were randomly devided into 2 groups and then instructed to intake either 100 mg of rooibos extract (0.21 mg of E6CG) or placebo for 2 weeks, respectively. The subjective dryness indices using the visual analog scale and the objective indices based on saliva flow rate, tear volume, and stratum corneum moisture content were evaluated before and after intake of the foods. This study was registered with UMIN Clinical Trials Registry as UMIN 000029492. Results Rooibos extract intake significantly improved the subjective dryness of mouth (P= 0.019), eye (P=0.006) and skin (P=0.030) and the objective indices of saliva flow rate (P= 0.045), tear volume (P=0.012) and stratum corneum moisture content (P=0.004). Conclusions This clinical study demonstrated that rooibos extract intake improves dryness of mouth, eye and skin.

UR - http://www.scopus.com/inward/record.url?scp=85050363307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050363307&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 997

EP - 1003

JO - Japanese Pharmacology and Therapeutics

JF - Japanese Pharmacology and Therapeutics

SN - 0386-3603

IS - 6

ER -