Effects of seasonal change on aryl hydrocarbon hydroxylase activity in human lymphocytes in a Japanese population

Chikako Kiyohara, Keitaro Tanaka, Tomio Hirohata

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Although much effort has been made to determine the relationship between aryl hydrocarbon hydroxylase (AHH) activity and susceptibility to lung cancer, the results have not been very consistent. We examined the effects of seasonal changes on the AHH activity of lymphocytes in healthy male adults (n = 239). The subjects completed a short questionnaire on their current lifestyle characteristics. This included the frequency of some selected dietary and environmental factors, the number of cigarettes smoked per day, the heating system and ventilation in their home, and their residential area. When the subjects were divided into four seasons according to the date of blood collection, a significant seasonal variation emerged in non-induced and 3-methylcholanthrene (MC)-induced AHH activities, which were adjusted for age and some environmental factors. Both non-induced and MC-induced AHH activities were highest in summer and lowest in winter. AHH inducibility (MC-induced/non-induced AHH activity) was relatively stable. Since seasonal change may affect AHH activity, it should be considered, alongside age and environmental factors, in epidemiological studies on the association between AHH activity in human lymphocytes and lung cancer.

元の言語英語
ページ(範囲)75-78
ページ数4
ジャーナルMedical Science Research
26
発行部数2
出版物ステータス出版済み - 3 21 1998

Fingerprint

Aryl Hydrocarbon Hydroxylases
Lymphocytes
Human Activities
Methylcholanthrene
Population
Lung Neoplasms
Age Factors
Tobacco Products
Heating
Ventilation
Life Style
Epidemiologic Studies
Blood

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Effects of seasonal change on aryl hydrocarbon hydroxylase activity in human lymphocytes in a Japanese population. / Kiyohara, Chikako; Tanaka, Keitaro; Hirohata, Tomio.

:: Medical Science Research, 巻 26, 番号 2, 21.03.1998, p. 75-78.

研究成果: ジャーナルへの寄稿記事

@article{c697c2a68120491d8132cffed8a23889,
title = "Effects of seasonal change on aryl hydrocarbon hydroxylase activity in human lymphocytes in a Japanese population",
abstract = "Although much effort has been made to determine the relationship between aryl hydrocarbon hydroxylase (AHH) activity and susceptibility to lung cancer, the results have not been very consistent. We examined the effects of seasonal changes on the AHH activity of lymphocytes in healthy male adults (n = 239). The subjects completed a short questionnaire on their current lifestyle characteristics. This included the frequency of some selected dietary and environmental factors, the number of cigarettes smoked per day, the heating system and ventilation in their home, and their residential area. When the subjects were divided into four seasons according to the date of blood collection, a significant seasonal variation emerged in non-induced and 3-methylcholanthrene (MC)-induced AHH activities, which were adjusted for age and some environmental factors. Both non-induced and MC-induced AHH activities were highest in summer and lowest in winter. AHH inducibility (MC-induced/non-induced AHH activity) was relatively stable. Since seasonal change may affect AHH activity, it should be considered, alongside age and environmental factors, in epidemiological studies on the association between AHH activity in human lymphocytes and lung cancer.",
author = "Chikako Kiyohara and Keitaro Tanaka and Tomio Hirohata",
year = "1998",
month = "3",
day = "21",
language = "English",
volume = "26",
pages = "75--78",
journal = "Medical Science Research",
issn = "0269-8951",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Effects of seasonal change on aryl hydrocarbon hydroxylase activity in human lymphocytes in a Japanese population

AU - Kiyohara, Chikako

AU - Tanaka, Keitaro

AU - Hirohata, Tomio

PY - 1998/3/21

Y1 - 1998/3/21

N2 - Although much effort has been made to determine the relationship between aryl hydrocarbon hydroxylase (AHH) activity and susceptibility to lung cancer, the results have not been very consistent. We examined the effects of seasonal changes on the AHH activity of lymphocytes in healthy male adults (n = 239). The subjects completed a short questionnaire on their current lifestyle characteristics. This included the frequency of some selected dietary and environmental factors, the number of cigarettes smoked per day, the heating system and ventilation in their home, and their residential area. When the subjects were divided into four seasons according to the date of blood collection, a significant seasonal variation emerged in non-induced and 3-methylcholanthrene (MC)-induced AHH activities, which were adjusted for age and some environmental factors. Both non-induced and MC-induced AHH activities were highest in summer and lowest in winter. AHH inducibility (MC-induced/non-induced AHH activity) was relatively stable. Since seasonal change may affect AHH activity, it should be considered, alongside age and environmental factors, in epidemiological studies on the association between AHH activity in human lymphocytes and lung cancer.

AB - Although much effort has been made to determine the relationship between aryl hydrocarbon hydroxylase (AHH) activity and susceptibility to lung cancer, the results have not been very consistent. We examined the effects of seasonal changes on the AHH activity of lymphocytes in healthy male adults (n = 239). The subjects completed a short questionnaire on their current lifestyle characteristics. This included the frequency of some selected dietary and environmental factors, the number of cigarettes smoked per day, the heating system and ventilation in their home, and their residential area. When the subjects were divided into four seasons according to the date of blood collection, a significant seasonal variation emerged in non-induced and 3-methylcholanthrene (MC)-induced AHH activities, which were adjusted for age and some environmental factors. Both non-induced and MC-induced AHH activities were highest in summer and lowest in winter. AHH inducibility (MC-induced/non-induced AHH activity) was relatively stable. Since seasonal change may affect AHH activity, it should be considered, alongside age and environmental factors, in epidemiological studies on the association between AHH activity in human lymphocytes and lung cancer.

UR - http://www.scopus.com/inward/record.url?scp=0031929523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031929523&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031929523

VL - 26

SP - 75

EP - 78

JO - Medical Science Research

JF - Medical Science Research

SN - 0269-8951

IS - 2

ER -