抄録
This study investigated the effects of sesamin and α-tocopherol on eicosanoid production and immune function in the rat. Male Brown-Norway rats, 4 weeks of age, were given either control, 0.5% sesamin, 0.5% α-tocopherol, or 0.5% sesamin plus 0.5% α-tocopherol diets for 3 weeks. When sesamin and tocopherol were given together, the proportion of 20 : 4n-6 phosphatidylcholine (PC) was significantly lowered in liver and lung, while that of 18 : 2n-6 and 20 : 3n-6 was significantly increased in liver. Simultaneous administration of these compounds significantly reduced the production by the lung of leukotriene C4 (LTC4), but there was no effect on the splenic LTC4 production and the plasma prostaglandin E2 concentration. Sesamin and tocopherol, either separately or in combination, significantly reduced both the proportion of splenic CD4+ and CD8+ T cells, but the change in the CD4+/CD8+ ratio was not significant. The effects of sesamin and tocopherol feeding on serum levels of IgA, IgE, and IgG were not so marked, but tocopherol significantly decreased the serum IgM level. These results suggest that the feeding of sesamin and tocopherol suppress LTC4 production through the decrease in the arachidonic acid level in lung PC.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1855-1858 |
| ページ数 | 4 |
| ジャーナル | Bioscience, biotechnology, and biochemistry |
| 巻 | 58 |
| 発行部数 | 10 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 1994 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
これを引用
Effects of Sesamin and α-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats. / Gu, Jiongyan; Nonaka, Michiko; Yamada, Koji; Yoshimura, Kazunari; Takasugi, Mikako; Ito, Yuji; Sugano, Michihiro.
：: Bioscience, biotechnology, and biochemistry, 巻 58, 番号 10, 01.01.1994, p. 1855-1858.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Effects of Sesamin and α-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats
AU - Gu, Jiongyan
AU - Nonaka, Michiko
AU - Yamada, Koji
AU - Yoshimura, Kazunari
AU - Takasugi, Mikako
AU - Ito, Yuji
AU - Sugano, Michihiro
PY - 1994/1/1
Y1 - 1994/1/1
N2 - This study investigated the effects of sesamin and α-tocopherol on eicosanoid production and immune function in the rat. Male Brown-Norway rats, 4 weeks of age, were given either control, 0.5% sesamin, 0.5% α-tocopherol, or 0.5% sesamin plus 0.5% α-tocopherol diets for 3 weeks. When sesamin and tocopherol were given together, the proportion of 20 : 4n-6 phosphatidylcholine (PC) was significantly lowered in liver and lung, while that of 18 : 2n-6 and 20 : 3n-6 was significantly increased in liver. Simultaneous administration of these compounds significantly reduced the production by the lung of leukotriene C4 (LTC4), but there was no effect on the splenic LTC4 production and the plasma prostaglandin E2 concentration. Sesamin and tocopherol, either separately or in combination, significantly reduced both the proportion of splenic CD4+ and CD8+ T cells, but the change in the CD4+/CD8+ ratio was not significant. The effects of sesamin and tocopherol feeding on serum levels of IgA, IgE, and IgG were not so marked, but tocopherol significantly decreased the serum IgM level. These results suggest that the feeding of sesamin and tocopherol suppress LTC4 production through the decrease in the arachidonic acid level in lung PC.
AB - This study investigated the effects of sesamin and α-tocopherol on eicosanoid production and immune function in the rat. Male Brown-Norway rats, 4 weeks of age, were given either control, 0.5% sesamin, 0.5% α-tocopherol, or 0.5% sesamin plus 0.5% α-tocopherol diets for 3 weeks. When sesamin and tocopherol were given together, the proportion of 20 : 4n-6 phosphatidylcholine (PC) was significantly lowered in liver and lung, while that of 18 : 2n-6 and 20 : 3n-6 was significantly increased in liver. Simultaneous administration of these compounds significantly reduced the production by the lung of leukotriene C4 (LTC4), but there was no effect on the splenic LTC4 production and the plasma prostaglandin E2 concentration. Sesamin and tocopherol, either separately or in combination, significantly reduced both the proportion of splenic CD4+ and CD8+ T cells, but the change in the CD4+/CD8+ ratio was not significant. The effects of sesamin and tocopherol feeding on serum levels of IgA, IgE, and IgG were not so marked, but tocopherol significantly decreased the serum IgM level. These results suggest that the feeding of sesamin and tocopherol suppress LTC4 production through the decrease in the arachidonic acid level in lung PC.
UR - http://www.scopus.com/inward/record.url?scp=85007688798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007688798&partnerID=8YFLogxK
U2 - 10.1271/bbb.58.1855
DO - 10.1271/bbb.58.1855
M3 - Article
VL - 58
SP - 1855
EP - 1858
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 10
ER -