Effects of synthetic human atrial natriuretic peptide on the human coronary circulation in subjects with normal coronary arteries

Kensuke Egashira, Tetsuzi Inou, Tsutomu Imaizumi, Hitonobu Tomoike, Akira Takeshita

    研究成果: Contribution to journalArticle査読

    13 被引用数 (Scopus)

    抄録

    Atrial natriuretic peptide (ANP) is recognized as an “endogenous vasodilator”. The purpose of this study was to determine the effects of a clinical therapeutic dose of synthetic alpha-human ANP on the coronary circulation in 15 subjects with normal coronary arteries and normal ventricular function. The epicardial coronary arterial diameter was measured by selective coronary arteriography. Coronary blood flow was estimated from the arterial cross-sectional area and the flow velocity determined using an subselective intracoronary Doppler catheter. ANP, 0.03 micrograms/min/kg given intravenously over 15 minutes, caused a dilation of the large epicardial coronary artery (n = 8): the diameter of the proximal left anterior descending artery dilated from 2.6 ± 0.4 to 3.1 ± 0.5 mm (p<0.01). Mean arterial pressure decreased from 89 ± 5 to 83 ± 5 mmHg (p<0.01); heart rate did not change during ANP infusion. Estimated coronary blood flow significantly increased (n = 6, p<0.01), and thus the coronary vascular resistance decreased after ANP infusion, suggesting an ANP-induced dilation of resistance vessels. The present study demonstrates that in human subjects a clinical dose of ANP by intravenous infusion dilates both the large epicardial and small resistance coronary vessels. These results suggest a potenitally beneficial role for ANP in reducing the severity of myocardial ischemia in patients with ischemic heart disease.

    本文言語英語
    ページ(範囲)1050-1056
    ページ数7
    ジャーナルJAPANESE CIRCULATION JOURNAL
    55
    11
    DOI
    出版ステータス出版済み - 1991

    All Science Journal Classification (ASJC) codes

    • 生理学
    • 循環器および心血管医学

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