Effects of tacrolimus (FK506) on the development of osteonecrosis in a rabbit model

Keita Miyanishi, Takuaki Yamamoto, Takahiko Irisa, Akihisa Yamashita, Goro Motomura, Seiya Jingushi, Yukihide Iwamoto

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

The present study examined the effects of tacrolimus (FK506) on the development of osteonecrosis in rabbits. In Experiment A, rabbits were given FK506, and also given a single dose of steroid. Control rabbits were given the same dose of steroid only. In Experiment B, rabbits were given FK506 and a reduced dose of steroid. The results showed that addition of FK506 did not change the number of rabbits with osteonecrosis when an identical steroid dose was given. When the steroid dose was reduced, the osteonecrosis incidence significantly decreased (p < 0.01). These results suggest that the clinically reported decrease in the osteonecrosis incidence following the introduction of FK506 is most likely attributable to the lower doses of steroids.

本文言語英語
ページ(範囲)79-90
ページ数12
ジャーナルImmunopharmacology and Immunotoxicology
30
1
DOI
出版ステータス出版済み - 3 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 毒物学
  • 薬理学

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