Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice

Tsutomu Suzuki, Hideaki Kato, Makoto Tsuda, Hajime Suzuki, Miwa Misawa

研究成果: Contribution to journalArticle査読

51 被引用数 (Scopus)

抄録

The effects of ifenprodil, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on the morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.) produced a dose-related place preference in mice. In contrast, ifenprodil alone (5-20 mg/kg, i.p.) did not produce either preference or aversion for the drug-associated place. Pretreatment with ifenprodil (5-20 mg/kg, i.p.) suppressed the place preference produced by morphine in a dose-dependent manner. These results indicate that ifenprodil suppresses the rewarding effect produced by morphine.

本文言語英語
ページ(範囲)PL151-PL156
ジャーナルLife Sciences
64
12
DOI
出版ステータス出版済み - 2 12 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)

フィンガープリント

「Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル