Effects of the superoxide dismutase mimetic tempol on impaired endothelium-dependent and endothelium-independent relaxations in type II diabetic rats

Hideyuki Oniki, Kenichi Goto, Koji Fujii, Yasuo Kansui, Noboru Murakami, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Endothelium-derived hyperpolarizing factor (EDHF)-mediated hyperpolarization and relaxation, and endothelium-independent relaxations to the nitric oxide donor sodium nitroprusside and the adenosine 5′-triphosphate (ATP)-sensitive K+-channel opener levcromakalim were both impaired in mesenteric arteries of type II diabetic Goto-Kakizaki rats. The treatment with the superoxide dismutase mimetic tempol or its combination with the angiotensin II type 1 receptor blocker candesartan failed to improve EDHF-mediated responses, although both treatments partially improved endothelium-independent relaxations. These findings suggest that increased oxidative stress may in part account for the impaired endothelium-independent relaxations in diabetes, while it does not play a major role in the impaired EDHF-mediated responses.

元の言語英語
ページ(範囲)112-119
ページ数8
ジャーナルClinical and Experimental Hypertension
35
発行部数2
DOI
出版物ステータス出版済み - 4 8 2013

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Superoxide Dismutase
Endothelium
Cromakalim
Angiotensin II Type 1 Receptor Blockers
Mesenteric Arteries
Nitric Oxide Donors
Nitroprusside
tempol
Oxidative Stress
Adenosine Triphosphate

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

これを引用

Effects of the superoxide dismutase mimetic tempol on impaired endothelium-dependent and endothelium-independent relaxations in type II diabetic rats. / Oniki, Hideyuki; Goto, Kenichi; Fujii, Koji; Kansui, Yasuo; Murakami, Noboru; Ohtsubo, Toshio; Matsumura, Kiyoshi; Kitazono, Takanari.

:: Clinical and Experimental Hypertension, 巻 35, 番号 2, 08.04.2013, p. 112-119.

研究成果: ジャーナルへの寄稿記事

Oniki, Hideyuki ; Goto, Kenichi ; Fujii, Koji ; Kansui, Yasuo ; Murakami, Noboru ; Ohtsubo, Toshio ; Matsumura, Kiyoshi ; Kitazono, Takanari. / Effects of the superoxide dismutase mimetic tempol on impaired endothelium-dependent and endothelium-independent relaxations in type II diabetic rats. :: Clinical and Experimental Hypertension. 2013 ; 巻 35, 番号 2. pp. 112-119.
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AU - Murakami, Noboru

AU - Ohtsubo, Toshio

AU - Matsumura, Kiyoshi

AU - Kitazono, Takanari

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