Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics

H. Aizawa, H. Inoue, H. Nakano, K. Matsumoto, M. Yoshida, S. Fukuyama, H. Koto, N. Hara

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

We examined effects of a thromboxane A2 (TXA2) antagonist seratrodast on airway hyperresponsiveness, exhaled nitric oxide (NO), and eosinophils in induced sputum in 14 asthmatics. Subjects were administered 80 mg of seratrodast once a day for 4 weeks. Respiratory conductance (Grs) was measured by the forced oscillation method and airway responsiveness was evaluated as the inhaled dose of methacholine, which induced 35% decrease in Grs. Subjects breathed into a Teflon bag, and NO concentration in the bag was measured by a chemiluminescence analyzer. Induced sputum comprised the entire expectorate produced during a 20 min inhalation of 3% saline, and was analyzed for total and differential cell counts. Airway hyperresponsiveness was significantly decreased by seratrodast. By contrast, no differences in either exhaled NO or percentage of eosinophils in sputum were observed before or after seratrodast. We conclude that seratrodast may attenuate airway hyperresponsiveness, presumably by antagonizing TXA2 released from the inflamed airways.

本文言語英語
ページ(範囲)185-190
ページ数6
ジャーナルProstaglandins Leukotrienes and Essential Fatty Acids
59
3
DOI
出版ステータス出版済み - 9 1998

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

フィンガープリント 「Effects of thromboxane A<sub>2</sub> antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル