Effects of various ammonium salts, amines, polyamines and α-methylornithine on rRNA synthesis in neurula cells of Xenopus laevis and Xenopus borealis

Koichiro Shiokawa, Yuichi Kawazoe, Kosuke Tashiro, K. Yamana

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Xenopus neurula cells were cultured in a medium that contained ammonium salts, amines, polyamines or α-methylornithine, and their rRNA synthesis was examined. All the ammonium salts and amines, but not polyamines, were strong and selective inhibitors of rRNA synthesis at 1.25-5.0 mM. α-Methylornithine did not inhibit rRNA synthesis, although it inhibited ornithine decarboxylase, an enzyme claimed to be a direct stimulator of rRNA synthesis. During the treatment ammonium ions and monomethylamines were accumulated within the treated cells. However, monomethylamines did not induce the accumulation of ammonium ions, and vice versa. Ammonium salts and amines also selectively inhibited rRNA synthesis in Xenopus borealis neurula cells.

本文言語英語
ページ(範囲)101-108
ページ数8
ジャーナルCell Differentiation
18
2
DOI
出版ステータス出版済み - 3 1986
外部発表はい

All Science Journal Classification (ASJC) codes

  • 発生生物学

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