抄録
In this interventional study, a randomized controlled trial was used to evaluate the short-term effects of xylitol-containing chewing gum on the salivary microbiota. In total, 70 healthy adult men recruited from the Japan Ground Self Defense Force participated in the study during a 2-day training at Yamaguchi camp, Yamaguchi Prefecture, Japan. The men were randomly divided into two groups: one group chewed two pieces of xylitol-containing chewing gum 7 times/day for 2 days (n = 34) and the other did not (n = 36). Baseline and follow-up stimulated saliva samples were collected and the salivary microbial composition was assessed using the 16S rRNA gene next-generation sequencing analysis. The total salivary bacterial count was quantified using a quantitative real-time PCR system. No statistically significant difference was found between the two groups regarding any parameter analyzed in the baseline samples; however, the follow-up samples of the test group showed significantly lower total salivary bacterial count than those of the control group. Conversely, no significant difference was observed in the overall composition of the salivary microbiota between the baseline and follow-up samples of the two groups. These results indicate that xylitol-containing chewing gum inhibits the increase in total salivary bacteria over a short time during which the salivary microbial composition is not affected.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 588-594 |
| ページ数 | 7 |
| ジャーナル | Journal of Oral Science |
| 巻 | 60 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | 出版済み - 12 1 2018 |
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All Science Journal Classification (ASJC) codes
- Dentistry(all)
これを引用
Effects of xylitol-containing chewing gum on the oral microbiota. / Takeuchi, Kenji; Asakawa, Mikari; Hashiba, Takafumi; Takeshita, Toru; Saeki, Youji; Yamashita, Yoshihisa.
：: Journal of Oral Science, 巻 60, 番号 4, 01.12.2018, p. 588-594.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Effects of xylitol-containing chewing gum on the oral microbiota
AU - Takeuchi, Kenji
AU - Asakawa, Mikari
AU - Hashiba, Takafumi
AU - Takeshita, Toru
AU - Saeki, Youji
AU - Yamashita, Yoshihisa
PY - 2018/12/1
Y1 - 2018/12/1
N2 - In this interventional study, a randomized controlled trial was used to evaluate the short-term effects of xylitol-containing chewing gum on the salivary microbiota. In total, 70 healthy adult men recruited from the Japan Ground Self Defense Force participated in the study during a 2-day training at Yamaguchi camp, Yamaguchi Prefecture, Japan. The men were randomly divided into two groups: one group chewed two pieces of xylitol-containing chewing gum 7 times/day for 2 days (n = 34) and the other did not (n = 36). Baseline and follow-up stimulated saliva samples were collected and the salivary microbial composition was assessed using the 16S rRNA gene next-generation sequencing analysis. The total salivary bacterial count was quantified using a quantitative real-time PCR system. No statistically significant difference was found between the two groups regarding any parameter analyzed in the baseline samples; however, the follow-up samples of the test group showed significantly lower total salivary bacterial count than those of the control group. Conversely, no significant difference was observed in the overall composition of the salivary microbiota between the baseline and follow-up samples of the two groups. These results indicate that xylitol-containing chewing gum inhibits the increase in total salivary bacteria over a short time during which the salivary microbial composition is not affected.
AB - In this interventional study, a randomized controlled trial was used to evaluate the short-term effects of xylitol-containing chewing gum on the salivary microbiota. In total, 70 healthy adult men recruited from the Japan Ground Self Defense Force participated in the study during a 2-day training at Yamaguchi camp, Yamaguchi Prefecture, Japan. The men were randomly divided into two groups: one group chewed two pieces of xylitol-containing chewing gum 7 times/day for 2 days (n = 34) and the other did not (n = 36). Baseline and follow-up stimulated saliva samples were collected and the salivary microbial composition was assessed using the 16S rRNA gene next-generation sequencing analysis. The total salivary bacterial count was quantified using a quantitative real-time PCR system. No statistically significant difference was found between the two groups regarding any parameter analyzed in the baseline samples; however, the follow-up samples of the test group showed significantly lower total salivary bacterial count than those of the control group. Conversely, no significant difference was observed in the overall composition of the salivary microbiota between the baseline and follow-up samples of the two groups. These results indicate that xylitol-containing chewing gum inhibits the increase in total salivary bacteria over a short time during which the salivary microbial composition is not affected.
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UR - http://www.scopus.com/inward/citedby.url?scp=85059237249&partnerID=8YFLogxK
U2 - 10.2334/josnusd.17-0446
DO - 10.2334/josnusd.17-0446
M3 - Article
VL - 60
SP - 588
EP - 594
JO - Journal of oral science
JF - Journal of oral science
SN - 1343-4934
IS - 4
ER -