Efferocytosis during myocardial infarction

研究成果: Contribution to journalReview article査読

抄録

Myocardial infarction is one of the major causes of death worldwide. Many heart cells die during myocardial infarction through various processes such as necrosis, apoptosis, necroptosis, autophagy-related cell death, pyroptosis and ferroptosis. These dead cells in infarcted hearts expose the so-called 'eat-me' signals, such as phosphatidylserine, on their surfaces, enhancing their removal by professional and non-professional phagocytes. Clearance of dead cells by phagocytes in the diseased hearts plays a crucial role in the pathology of myocardial infarction by inhibiting the inflammatory responses caused by the leakage of contents from dead cells. This review focuses on the rapidly growing understanding of the molecular mechanisms of dead cell phagocytosis, termed efferocytosis, during myocardial infarction, which contributes to the pathophysiology of myocardial infarction.

本文言語英語
ページ(範囲)1-6
ページ数6
ジャーナルJournal of biochemistry
168
1
DOI
出版ステータス出版済み - 7 1 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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