Efficacy of intravenous administration of atrial natriuretic peptide after cardiac surgery in neonates and infants

E. Murakami, H. Kado, M. Masuda, Y. Shiokawa, K. Fukae, Y. Kanegae, H. Iwaki, T. Shirota, H. Yasui

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Intravenous infusion of alpha-human atrial natriuretic polypeptide (hANP) and furosemide was performed in 12 patients (4: TGA, 3: univentricular heart, 3: HLHS, 2: VSD) after cardiopulmonary bypass. Their mean age at the operation was 68 days (6 patients in neonate), the mean body weight was 3.3 kg. All patients were treated with nitroglycerin in dose of 2 micrograms/kg/min and chlorpromazine in dose of 2.8 micrograms/kg/min and catecholamine in mean dose of 6.5 micrograms/kg/min. The criteria of indication for hANP was poor effect of furosemide alone. The hANP was given for 6-144 hours in dose of 0.1-0.2 microgram/kg/min. With the hANP and furosemide infusion, urine volume increased from 85.0 +/- 14.2 ml/kg/day to 107.9 +/- 25.3 ml/kg/day (p < 0.05), whereas the systemic arterial pressure, the central venous pressure and the renal function were unchanged. We conclude that the combination of the hANP and the furosemide is very effective in neonates and infants.

本文言語英語
ページ(範囲)822-825
ページ数4
ジャーナルKyobu geka. The Japanese journal of thoracic surgery
52
10
出版ステータス出版済み - 9月 1999
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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