Efficacy of preoperative transcatheter arterial chemoembolization combined with systemic chemotherapy for treatment of unresectable hepatoblastoma in children

Masakazu Hirakawa, Akihiro Nishie, Yoshiki Asayama, Nobuhiro Fujita, Kousei Ishigami, Tatsurou Tajiri, Tomoaki Taguchi, Hiroshi Honda

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Purpose: The purpose of this study was to evaluate, retrospectively, the clinical efficacy of preoperative transcatheter arterial chemoembolization (TACE) combined with systemic chemotherapy for unresectable hepatoblastoma. Materials and methods: Five boys and three girls (mean age 15.2 months) were treated with preoperative TACE combined with systemic chemotherapy for unresectable hepatoblastomas. Mean tumor diameter and mean alfa-fetoprotein (AFP) level were 11.8 cm and 549,386 ng/mL, respectively. Pretreatment, the extent of disease (PRETEXT) was: II, 1; III, 6; IV, 1. For all patients, preoperative systemic chemotherapy was administered before TACE. At each TACE, carboplatin and adriamycin mixed with iodized oil were infused into the feeding arteries. Tumor response and prognosis after treatment were evaluated. Results: TACE resulted in few Grade 1 adverse effects (AEs), without G3 or more AEs, according to CTACAE 3.0. Mean tumor shrinkage was 60.9 %, and the mean AFP decrease from initial levels was 94.8 %. In all cases TACE combined with systemic chemotherapy enabled subsequent safe and complete surgical resection. After a mean follow-up of 59 months, tumor-free survival was 75 %. Conclusion: Preoperative TACE combined with systemic chemotherapy was effective in inducing surgical resectability of unresectable hepatoblastoma.

本文言語英語
ページ(範囲)529-536
ページ数8
ジャーナルJapanese Journal of Radiology
32
9
DOI
出版ステータス出版済み - 9 1 2014

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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