Efficient cross-linking reactions by functional nucleobases capable of in situ activation under neutral conditions.

Fumi Nagatsugi, Yasushi Suenaga, Shigeki Sasaki

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

We have previously described that the oligonucleotides containing phenylsulfide derivatives of 2-amino-6-vinylpurine nucleoside analog are activated within duplex to form cross-link toward cytidine selectively at the target site. However, the cross-linking reaction via the in-situ activation needs acidic conditions. In this paper, we wish to report that the new 2-amino-6-vinylpurine derivatives designed to have a structure of "double-activation" for in-situ activation exhibit fast cross-linking with cytidine under neutral conditions.

本文言語英語
ページ(範囲)155-156
ページ数2
ジャーナルNucleic acids research. Supplement (2001)
3
DOI
出版ステータス出版済み - 2003

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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