Efficient transformation of propargylic alcohols to α,β-unsaturated aldehydes catalyzed by ruthenium/water under neutral conditions

Toshiaki Suzuki, Makoto Tokunaga, Yasuo Wakatsuki

研究成果: Contribution to journalArticle査読

73 被引用数 (Scopus)

抄録

α,β-Unsaturated aldehydes were selectively obtained in high yields from propargylic alcohols in aqueous solutions using RuCpCl(PR3)2 (Cp=η5-C5H5) as a catalyst. Of the tert-phosphine ligands examined, PMe3 gave the most satisfactory results. Typically, RuCpCl(PMe3)2 (5 mol%) catalyzed the transformation of oct-1-yn-3-ol at 100°C to give 2-octenal in an isolated yield of 85% (E/Z=80/20).

本文言語英語
ページ(範囲)7531-7533
ページ数3
ジャーナルTetrahedron Letters
43
42
DOI
出版ステータス出版済み - 10 14 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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