ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles

Yuzuru Kato, Tokuko Iwamori, Youichirou Ninomiya, Takashi Kohda, Jyunko Miyashita, Mikiko Sato, Yumiko Saga

研究成果: ジャーナルへの寄稿学術誌査読

10 被引用数 (Scopus)

抄録

Formation of primordial follicles is a fundamental, early process in mammalian oogenesis. However, little is known about the underlying mechanisms. We herein report that the RNA-binding proteins ELAVL2 and DDX6 are indispensable for the formation of quiescent primordial follicles in mouse ovaries. We show that Elavl2 knockout females are infertile due to defective primordial follicle formation. ELAVL2 associates with mRNAs encoding components of P-bodies (cytoplasmic RNP granules involved in the decay and storage of RNA) and directs the assembly of P-body-like granules by promoting the translation of DDX6 in oocytes prior to the formation of primordial follicles. Deletion of Ddx6 disturbs the assembly of P-body-like granules and severely impairs the formation of primordial follicles, indicating the potential importance of P-body-like granules in the formation of primordial follicles. Furthermore, Ddx6-deficient oocytes are abnormally enlarged due to misregulated PI3K-AKT signaling. Our data reveal that an ELAVL2-directed post-transcriptional network is essential for the formation of quiescent primordial follicles.

本文言語英語
論文番号e48251
ジャーナルEMBO Reports
20
12
DOI
出版ステータス出版済み - 12月 5 2019

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 遺伝学

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