Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

Keimei Yoshida; Keita Saku; Kazuhiro Kamada; Kohtaro Abe; Mariko Tanaka-Ishikawa; Takeshi Tohyama; Takuya Nishikawa; Takuya Kishi; Kenji Sunagawa; Hiroyuki Tsutsui

doi:10.1016/j.jacbts.2018.07.007

Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

Keimei Yoshida, Keita Saku, Kazuhiro Kamada, Kohtaro Abe, Mariko Tanaka-Ishikawa, Takeshi Tohyama, Takuya Nishikawa, Takuya Kishi, Kenji Sunagawa, Hiroyuki Tsutsui

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

22 被引用数 (Scopus)

抄録

This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.

本文言語	英語
ページ（範囲）	657-671
ページ数	15
ジャーナル	JACC: Basic to Translational Science
巻	3
号	5
DOI	https://doi.org/10.1016/j.jacbts.2018.07.007
出版ステータス	出版済み - 10月 2018

!!!All Science Journal Classification (ASJC) codes

循環器および心血管医学

文献へのアクセス

10.1016/j.jacbts.2018.07.007

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フィンガープリント

「Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Yoshida, K., Saku, K., Kamada, K., Abe, K., Tanaka-Ishikawa, M., Tohyama, T., Nishikawa, T., Kishi, T., Sunagawa, K., & Tsutsui, H. (2018). Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension. JACC: Basic to Translational Science, 3(5), 657-671. https://doi.org/10.1016/j.jacbts.2018.07.007

Yoshida, K, Saku, K, Kamada, K, Abe, K, Tanaka-Ishikawa, M, Tohyama, T, Nishikawa, T, Kishi, T, Sunagawa, K & Tsutsui, H 2018, 'Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension', JACC: Basic to Translational Science, vol. 3, no. 5, pp. 657-671. https://doi.org/10.1016/j.jacbts.2018.07.007

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abstract = "This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.",

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