Electrochemical enzymatic biosensor with long-term stability using hybrid mesoporous membrane

Tetsuji Itoh, Takeshi Shimomura, Akari Hayashi, Akira Yamaguchi, Norio Teramae, Masatoshi Ono, Tatsuo Tsunoda, Fujio Mizukami, Galen D. Stucky, Taka Aki Hanaoka

研究成果: ジャーナルへの寄稿学術誌査読

22 被引用数 (Scopus)

抄録

An acetylcholinesterase-immobilized sensor unit was successfully prepared by encapsulating the enzyme within hybrid mesoporous silica membranes (F127-MST). Through a novel combination with tetracyanoquinodimethane, both acetylcholine and organophosphorus pesticides were successfully detected with high sensitivity. Furthermore, we manufactured the working prototype of an enzyme sensor with this sensor unit for detecting dichlorvos, aldicarb and parathion. At present, the detection limit in this working prototype either equaled or surpassed that of others. Also, we have the advantage of increased stability of the enzyme against the outer environment by encapsulation of the enzymes into a silica nanospace. Consequently, acetylcholinesterase immobilized in F127-MST is a practical sensor with high sensitivity, reusability, and storage stability.

本文言語英語
ページ(範囲)4654-4660
ページ数7
ジャーナルAnalyst
139
18
DOI
出版ステータス出版済み - 8月 11 2014

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 環境化学
  • 分光学
  • 電気化学

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