Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging

D. David Jebaraj, A. Milton Franklin Benial, Kazuhiro Ichikawa, Ken-Ichi Yamada, Hideo Utsumi

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Electron Spin Resonance (ESR) studies were carried out for 2 mM concentration of 15N labeled carbamoyl-PROXYL, carboxy-PROXYL, MC-PROXYL and their deuterated derivatives using X-band ESR spectrometer. The ESR parameters such as linewidth, hyperfine coupling constant, g-factor, spin-spin relaxation time were determined. The lineshape analysis was also carried out. The observed linewidth values are ̃50% higher for undeuterated nitroxyl radicals compared with their deuterated derivatives. The lineshape analysis reveals that the observed ESR lineshape is a voigt lineshape, which is the convolution of a lorentzian and guassian profile. ESR lineshape analysis results that the lorentzian contribution is ̃20% higher for deuterated nitroxyl radicals compared with undeuterated nitroxyl radicals. The observed spin-spin relaxartion time for deuterated nitroxyl radicals is ̃50% longer compared with undeuterated nitroxyl radicals. The g value indicates the isotropic nature of nitroxyl radicals in pure water. From these results, the deuterated nitroxyl radicals are suitable spin probes for ESR/Overhauser- enhanced magnetic resonance (OMR) studies.

本文言語英語
ホスト出版物のタイトルProceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013
ページ1171-1172
ページ数2
DOI
出版ステータス出版済み - 7 18 2013
イベントInternational Conference on Recent Trends in Applied Physics and Material Science, RAM 2013 - Bikaner, Rajasthan, インド
継続期間: 2 1 20132 2 2013

出版物シリーズ

名前AIP Conference Proceedings
1536
ISSN(印刷版)0094-243X
ISSN(電子版)1551-7616

その他

その他International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013
Countryインド
CityBikaner, Rajasthan
Period2/1/132/2/13

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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