Elevated bile amylase level without pancreaticobiliary maljunction is a risk factor for gallbladder carcinoma

Takaaki Fujimoto, Ohtsuka Takao, Yohei Nakashima, Yoshitaka Gotoh, Kenjiro Date, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yoshinao Oda, Masafumi Nakamura

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Background: Elevated bile amylase level in patients with pancreaticobiliary maljunction (PBM) or high confluence of pancreaticobiliary ducts (HCPBD) is well known as a risk factor for gallbladder carcinoma (GBC) development. However, the effects of occult pancreaticobiliary reflux (OPR), a condition characterized by high bile amylase level in the presence of an anatomically normal pancreaticobiliary junction, on GBC development remain unclear. The aim of this study was to assess the relationship between OPR and GBC. Methods: Clinicopathological data of 52 patients who were preoperatively diagnosed with gallbladder (GB) tumor (22 malignant, 30 benign) were retrospectively reviewed. All of the patients underwent preoperative endoscopic retrograde cholangiopancreatography to evaluate pancreaticobiliary junction morphology and bile amylase level. The relationship between the histological diagnosis of GB lesions, and pancreaticobiliary junction morphology and bile amylase level were investigated. Results: Pancreaticobiliary maljunction, HCPBD, and normal pancreaticobiliary junction (NPJ) were identified in 12, nine, and 31 patients, respectively. The rates of GBC in patients with PBM, HCPBD, and NPJ were 58% (7/12), 67% (6/9), and 29% (9/31), respectively. Of the 31 patients with NPJ, 22 had OPR and nine of these had GBC. None of the patients with NPJ and normal bile amylase level had GBC. Additionally, among patients with NPJ, bile amylase level was significantly higher in patients with GBC than in patients with benign tumors. Conclusions: Occult pancreaticobiliary reflux, like PBM and HCPBD, is a risk factor for GBC development.

元の言語英語
ページ(範囲)103-108
ページ数6
ジャーナルJournal of Hepato-Biliary-Pancreatic Sciences
24
発行部数2
DOI
出版物ステータス出版済み - 2 1 2017

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Amylases
Gallbladder
Bile
Carcinoma
Endoscopic Retrograde Cholangiopancreatography
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology

これを引用

Elevated bile amylase level without pancreaticobiliary maljunction is a risk factor for gallbladder carcinoma. / Fujimoto, Takaaki; Takao, Ohtsuka; Nakashima, Yohei; Gotoh, Yoshitaka; Date, Kenjiro; Mori, Yasuhisa; Sadakari, Yoshihiko; Takahata, Shunichi; Oda, Yoshinao; Nakamura, Masafumi.

:: Journal of Hepato-Biliary-Pancreatic Sciences, 巻 24, 番号 2, 01.02.2017, p. 103-108.

研究成果: ジャーナルへの寄稿記事

Fujimoto, Takaaki ; Takao, Ohtsuka ; Nakashima, Yohei ; Gotoh, Yoshitaka ; Date, Kenjiro ; Mori, Yasuhisa ; Sadakari, Yoshihiko ; Takahata, Shunichi ; Oda, Yoshinao ; Nakamura, Masafumi. / Elevated bile amylase level without pancreaticobiliary maljunction is a risk factor for gallbladder carcinoma. :: Journal of Hepato-Biliary-Pancreatic Sciences. 2017 ; 巻 24, 番号 2. pp. 103-108.
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title = "Elevated bile amylase level without pancreaticobiliary maljunction is a risk factor for gallbladder carcinoma",
abstract = "Background: Elevated bile amylase level in patients with pancreaticobiliary maljunction (PBM) or high confluence of pancreaticobiliary ducts (HCPBD) is well known as a risk factor for gallbladder carcinoma (GBC) development. However, the effects of occult pancreaticobiliary reflux (OPR), a condition characterized by high bile amylase level in the presence of an anatomically normal pancreaticobiliary junction, on GBC development remain unclear. The aim of this study was to assess the relationship between OPR and GBC. Methods: Clinicopathological data of 52 patients who were preoperatively diagnosed with gallbladder (GB) tumor (22 malignant, 30 benign) were retrospectively reviewed. All of the patients underwent preoperative endoscopic retrograde cholangiopancreatography to evaluate pancreaticobiliary junction morphology and bile amylase level. The relationship between the histological diagnosis of GB lesions, and pancreaticobiliary junction morphology and bile amylase level were investigated. Results: Pancreaticobiliary maljunction, HCPBD, and normal pancreaticobiliary junction (NPJ) were identified in 12, nine, and 31 patients, respectively. The rates of GBC in patients with PBM, HCPBD, and NPJ were 58{\%} (7/12), 67{\%} (6/9), and 29{\%} (9/31), respectively. Of the 31 patients with NPJ, 22 had OPR and nine of these had GBC. None of the patients with NPJ and normal bile amylase level had GBC. Additionally, among patients with NPJ, bile amylase level was significantly higher in patients with GBC than in patients with benign tumors. Conclusions: Occult pancreaticobiliary reflux, like PBM and HCPBD, is a risk factor for GBC development.",
author = "Takaaki Fujimoto and Ohtsuka Takao and Yohei Nakashima and Yoshitaka Gotoh and Kenjiro Date and Yasuhisa Mori and Yoshihiko Sadakari and Shunichi Takahata and Yoshinao Oda and Masafumi Nakamura",
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T1 - Elevated bile amylase level without pancreaticobiliary maljunction is a risk factor for gallbladder carcinoma

AU - Fujimoto, Takaaki

AU - Takao, Ohtsuka

AU - Nakashima, Yohei

AU - Gotoh, Yoshitaka

AU - Date, Kenjiro

AU - Mori, Yasuhisa

AU - Sadakari, Yoshihiko

AU - Takahata, Shunichi

AU - Oda, Yoshinao

AU - Nakamura, Masafumi

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Background: Elevated bile amylase level in patients with pancreaticobiliary maljunction (PBM) or high confluence of pancreaticobiliary ducts (HCPBD) is well known as a risk factor for gallbladder carcinoma (GBC) development. However, the effects of occult pancreaticobiliary reflux (OPR), a condition characterized by high bile amylase level in the presence of an anatomically normal pancreaticobiliary junction, on GBC development remain unclear. The aim of this study was to assess the relationship between OPR and GBC. Methods: Clinicopathological data of 52 patients who were preoperatively diagnosed with gallbladder (GB) tumor (22 malignant, 30 benign) were retrospectively reviewed. All of the patients underwent preoperative endoscopic retrograde cholangiopancreatography to evaluate pancreaticobiliary junction morphology and bile amylase level. The relationship between the histological diagnosis of GB lesions, and pancreaticobiliary junction morphology and bile amylase level were investigated. Results: Pancreaticobiliary maljunction, HCPBD, and normal pancreaticobiliary junction (NPJ) were identified in 12, nine, and 31 patients, respectively. The rates of GBC in patients with PBM, HCPBD, and NPJ were 58% (7/12), 67% (6/9), and 29% (9/31), respectively. Of the 31 patients with NPJ, 22 had OPR and nine of these had GBC. None of the patients with NPJ and normal bile amylase level had GBC. Additionally, among patients with NPJ, bile amylase level was significantly higher in patients with GBC than in patients with benign tumors. Conclusions: Occult pancreaticobiliary reflux, like PBM and HCPBD, is a risk factor for GBC development.

AB - Background: Elevated bile amylase level in patients with pancreaticobiliary maljunction (PBM) or high confluence of pancreaticobiliary ducts (HCPBD) is well known as a risk factor for gallbladder carcinoma (GBC) development. However, the effects of occult pancreaticobiliary reflux (OPR), a condition characterized by high bile amylase level in the presence of an anatomically normal pancreaticobiliary junction, on GBC development remain unclear. The aim of this study was to assess the relationship between OPR and GBC. Methods: Clinicopathological data of 52 patients who were preoperatively diagnosed with gallbladder (GB) tumor (22 malignant, 30 benign) were retrospectively reviewed. All of the patients underwent preoperative endoscopic retrograde cholangiopancreatography to evaluate pancreaticobiliary junction morphology and bile amylase level. The relationship between the histological diagnosis of GB lesions, and pancreaticobiliary junction morphology and bile amylase level were investigated. Results: Pancreaticobiliary maljunction, HCPBD, and normal pancreaticobiliary junction (NPJ) were identified in 12, nine, and 31 patients, respectively. The rates of GBC in patients with PBM, HCPBD, and NPJ were 58% (7/12), 67% (6/9), and 29% (9/31), respectively. Of the 31 patients with NPJ, 22 had OPR and nine of these had GBC. None of the patients with NPJ and normal bile amylase level had GBC. Additionally, among patients with NPJ, bile amylase level was significantly higher in patients with GBC than in patients with benign tumors. Conclusions: Occult pancreaticobiliary reflux, like PBM and HCPBD, is a risk factor for GBC development.

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U2 - 10.1002/jhbp.421

DO - 10.1002/jhbp.421

M3 - Article

VL - 24

SP - 103

EP - 108

JO - Journal of Hepato-Biliary-Pancreatic Sciences

JF - Journal of Hepato-Biliary-Pancreatic Sciences

SN - 1868-6974

IS - 2

ER -