Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis

Hirofumi Inoue, Takeshi Matsushige, Takashi Ichiyama, Alato Okuno, Osamu Takikawa, Shozo Tomonaga, Banu Anlar, Deniz Yüksel, Yasushi Otsuka, Fumitaka Kohno, Madoka Hoshide, Shouichi Ohga, Shunji Hasegawa

研究成果: ジャーナルへの寄稿記事

抄録

Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.

元の言語英語
記事番号577088
ジャーナルJournal of Neuroimmunology
339
DOI
出版物ステータス出版済み - 2 15 2020

Fingerprint

Quinolinic Acid
Subacute Sclerosing Panencephalitis
Cerebrospinal Fluid
Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Measles virus
Neurodegenerative Diseases
Neurons
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

これを引用

Inoue, H., Matsushige, T., Ichiyama, T., Okuno, A., Takikawa, O., Tomonaga, S., ... Hasegawa, S. (2020). Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis. Journal of Neuroimmunology, 339, [577088]. https://doi.org/10.1016/j.jneuroim.2019.577088

Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis. / Inoue, Hirofumi; Matsushige, Takeshi; Ichiyama, Takashi; Okuno, Alato; Takikawa, Osamu; Tomonaga, Shozo; Anlar, Banu; Yüksel, Deniz; Otsuka, Yasushi; Kohno, Fumitaka; Hoshide, Madoka; Ohga, Shouichi; Hasegawa, Shunji.

:: Journal of Neuroimmunology, 巻 339, 577088, 15.02.2020.

研究成果: ジャーナルへの寄稿記事

Inoue, H, Matsushige, T, Ichiyama, T, Okuno, A, Takikawa, O, Tomonaga, S, Anlar, B, Yüksel, D, Otsuka, Y, Kohno, F, Hoshide, M, Ohga, S & Hasegawa, S 2020, 'Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis', Journal of Neuroimmunology, 巻. 339, 577088. https://doi.org/10.1016/j.jneuroim.2019.577088
Inoue, Hirofumi ; Matsushige, Takeshi ; Ichiyama, Takashi ; Okuno, Alato ; Takikawa, Osamu ; Tomonaga, Shozo ; Anlar, Banu ; Yüksel, Deniz ; Otsuka, Yasushi ; Kohno, Fumitaka ; Hoshide, Madoka ; Ohga, Shouichi ; Hasegawa, Shunji. / Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis. :: Journal of Neuroimmunology. 2020 ; 巻 339.
@article{2b5b65dd368b40dd97d0c13b67e59754,
title = "Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis",
abstract = "Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.",
author = "Hirofumi Inoue and Takeshi Matsushige and Takashi Ichiyama and Alato Okuno and Osamu Takikawa and Shozo Tomonaga and Banu Anlar and Deniz Y{\"u}ksel and Yasushi Otsuka and Fumitaka Kohno and Madoka Hoshide and Shouichi Ohga and Shunji Hasegawa",
year = "2020",
month = "2",
day = "15",
doi = "10.1016/j.jneuroim.2019.577088",
language = "English",
volume = "339",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

TY - JOUR

T1 - Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis

AU - Inoue, Hirofumi

AU - Matsushige, Takeshi

AU - Ichiyama, Takashi

AU - Okuno, Alato

AU - Takikawa, Osamu

AU - Tomonaga, Shozo

AU - Anlar, Banu

AU - Yüksel, Deniz

AU - Otsuka, Yasushi

AU - Kohno, Fumitaka

AU - Hoshide, Madoka

AU - Ohga, Shouichi

AU - Hasegawa, Shunji

PY - 2020/2/15

Y1 - 2020/2/15

N2 - Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.

AB - Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.

UR - http://www.scopus.com/inward/record.url?scp=85074724177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074724177&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2019.577088

DO - 10.1016/j.jneuroim.2019.577088

M3 - Article

AN - SCOPUS:85074724177

VL - 339

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

M1 - 577088

ER -