Emission characteristics of paliperidone from invega™ tablets in one-dose packages and the evaluation of patients

Hiroko Kito, Yasumi Ishida, Miki Kunimi, Yumiko Morooka, Takashi Hirowatari, Takahiro Akamine, Hana Hashimoto, Satoru Koyanagi, Shigehiro Ohdo, Hidetoshi Kamimura

研究成果: Contribution to journalArticle査読

抄録

Objectives Paliperidone tablets (INVEGA™) are dispensed in a sustained release preparation through osmotic pressure so that this drug is not prematurely pressed through the package before dosing and to avoid dispensing by the one-dose package. However, pressing through the package of the paliperidone tablet is hard and may be challenging for feeble patients. Therefore we dispensed the paliperidone tablet in a one-dose package and investigated the emission characteristics and impression of the patients. Methods We observed the appearance of the tablet and performed a dissolution test of the paliperidone tablet in the one-dose package. We also carried out a questionnaire survey for the patients administered the paliperidone tablets in the one-dose package. Results An appearance change of an INVEGA™ and amount fall of paliperidone were not noted for at least 90 days after preparation in the one-dose package. The emission characteristics of paliperidone from an INVEGA™ showed adapted behavior according to pharmaceutical standards for at least 90 days after preparation in the one-dose package. Seven of 8 patients replied that the one-dose package was useful to avoid missing doses. In addition, all patients hoped to receive medication by the one-dose package. Conclusions An improvement in medication adherence is anticipated for paliperidone using the one-dose package. (Jpn Pharmacol Ther 2016 ; 44 : 65-9).

本文言語英語
ページ(範囲)65-69
ページ数5
ジャーナルJapanese Pharmacology and Therapeutics
44
1
出版ステータス出版済み - 1 1 2016

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)

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