Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure

Hideo Nambu, Shingo Takada, Arata Fukushima, Junichi Matsumoto, Naoya Kakutani, Satoshi Maekawa, Ryosuke Shirakawa, Ippei Nakano, Takaaki Furihata, Takashi Katayama, Katsuma Yamanashi, Yoshikuni Obata, Akimichi Saito, Takashi Yokota, Shintaro Kinugawa

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

Decreased exercise capacity, which is an independent predictor of the poor prognosis of patients with heart failure (HF), is attributed to markedly impaired skeletal muscle mitochondrial function and fatty acid oxidation. Previous studies reported that the administration of an inhibitor of sodium-glucose cotransporter 2 (SGLT2) increases ketone body production and fat utilization in type 2 diabetic mice. In this study, we investigated the effects of SGLT2 inhibitor administration on exercise endurance and skeletal muscle mitochondrial function with fatty acid oxidation in a murine model of HF after the induction of myocardial infarction (MI). Two weeks post-MI, HF mice were divided into 2 groups, i.e., with or without treatment with the SGLT2 inhibitor empagliflozin (Empa, 300 mg/kg of food). Consistent with previous studies, urinary glucose and blood beta-hydroxybutyrate levels were increased in the HF+Empa mice compared with the sham and HF mice 4 weeks after the start of Empa administration. Exercise endurance capacity was limited in the HF mice but was ameliorated in the HF+Empa mice, without any effects on cardiac function, food intake, spontaneous physical activity, skeletal muscle strength, and skeletal muscle weight. Mitochondrial oxidative phosphorylation capacity with fatty acid substrates was reduced in the skeletal muscle of HF mice, and this decrease was ameliorated in the HF+Empa mice. Our results demonstrate that SGLT2 inhibitors may be novel therapeutics against reduced exercise endurance capacity in HF, by improving mitochondrial fatty acid oxidation in skeletal muscle.

本文言語英語
論文番号172810
ジャーナルEuropean Journal of Pharmacology
866
DOI
出版ステータス出版済み - 1 5 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pharmacology

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