Enantioselective Synthesis of Silacyclopentanes

Kazunobu Igawa, Daisuke Yoshihiro, Yusuke Abe, Katsuhiko Tomooka

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.

本文言語英語
ページ(範囲)5814-5818
ページ数5
ジャーナルAngewandte Chemie - International Edition
55
19
DOI
出版ステータス出版済み - 5 4 2016

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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