End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Motoki Ueda, Siyoong Seo, Baiju G. Nair, Stefan Müller, Eiki Takahashi, Takashi Arai, Tomonori Iyoda, Shin Ichiro Fujii, Satoshi Tsuneda, Yoshihiro Ito

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

Nanomaterial morphology is important for the targeted delivery of drugs to tissues as well as subsequent cellular uptake. Hollow nanotubes composed of peptides, with a diameter of 80 nm and various lengths (100, 200, 300, 600 nm), were successfully capped and sealed with a peptide hemisphere to encapsulate the anticancer drug, cisplatin. The torpedo-shaped nanocapsules with an aspect ratio (length/diameter) of 2.4 showed more rapid cellular uptake and accumulation at the tumor site compared with spherical analogues. Successful delivery of cisplatin to tumors was achieved in a mouse model and tumor growth was efficiently suppressed.

本文言語英語
ページ(範囲)305-312
ページ数8
ジャーナルACS nano
13
1
DOI
出版ステータス出版済み - 1 22 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 工学(全般)
  • 物理学および天文学(全般)

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