Endocannabinoid system modulates relapse to methamphetamine seeking: Possible mediation by the arachidonic acid cascade

Kusnandar Anggadiredja, Masanori Nakamichi, Takato Hiranita, Hiroyuki Tanaka, Yukihiro Shoyama, Shigenori Watanabe, Tsuneyuki Yamamoto

研究成果: ジャーナルへの寄稿記事

97 引用 (Scopus)

抄録

We clarified the modulating action of the endocannabinoid system, and its possible mediation by the arachidonic acid cascade, on the reinstatement of methamphetamine (METH)-seeking behavior, using the intravenous self-administration paradigm in rats. Following 12 days of self-administration of METH, the replacement of METH with saline resulted in a gradual decrease in lever press responses (extinction). Under extinction conditions, METH-priming or re-exposure to cues previously paired with METH infusion markedly increased the responses (reinstatement of drug-seeking). The cannabinoid CBI receptor antagonist, SR14171 6A, blocked this behavior. Although the cannabinoid agonist, Δ8-tetrahydrocannabinol (THC), had no effects by itself, coadministration of the agonist and METH at small doses reinstated the drug-seeking behavior. THC attenuated the effects of the reinstatement-inducing dose of METH, but enhanced the effect of cues. Either given repeatedly during the extinction or singly, 24 h before the first METH-priming or cues challenge, THC suppressed the reinstatement. In another set of experiments, we found that diclofenac, a cyclooxygenase inhibitor, also attenuated the reinstatement induced by exposure to cues or drug-priming. These results suggest that the endocannabinoid system, through possible mediation by the arachidonic acid cascade, serves as a modulator of the reinstating effects of METH-priming and cues. Extending the current view on the treatment of drug dependence, these results indicate that endocannabinoid-activating substances as well as cyclooxygenase inhibitors may be promising as antirelapse agents.

元の言語英語
ページ(範囲)1470-1478
ページ数9
ジャーナルNeuropsychopharmacology
29
発行部数8
DOI
出版物ステータス出版済み - 8 1 2004

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Endocannabinoids
Methamphetamine
Arachidonic Acid
Recurrence
Cues
Dronabinol
Self Administration
Cyclooxygenase Inhibitors
Drug-Seeking Behavior
Cannabinoid Receptor Antagonists
Cannabinoid Receptor Agonists
Diclofenac
Pharmaceutical Preparations
Intravenous Administration
Substance-Related Disorders

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health

これを引用

Anggadiredja, K., Nakamichi, M., Hiranita, T., Tanaka, H., Shoyama, Y., Watanabe, S., & Yamamoto, T. (2004). Endocannabinoid system modulates relapse to methamphetamine seeking: Possible mediation by the arachidonic acid cascade. Neuropsychopharmacology, 29(8), 1470-1478. https://doi.org/10.1038/sj.npp.1300454

Endocannabinoid system modulates relapse to methamphetamine seeking : Possible mediation by the arachidonic acid cascade. / Anggadiredja, Kusnandar; Nakamichi, Masanori; Hiranita, Takato; Tanaka, Hiroyuki; Shoyama, Yukihiro; Watanabe, Shigenori; Yamamoto, Tsuneyuki.

:: Neuropsychopharmacology, 巻 29, 番号 8, 01.08.2004, p. 1470-1478.

研究成果: ジャーナルへの寄稿記事

Anggadiredja, K, Nakamichi, M, Hiranita, T, Tanaka, H, Shoyama, Y, Watanabe, S & Yamamoto, T 2004, 'Endocannabinoid system modulates relapse to methamphetamine seeking: Possible mediation by the arachidonic acid cascade', Neuropsychopharmacology, 巻. 29, 番号 8, pp. 1470-1478. https://doi.org/10.1038/sj.npp.1300454
Anggadiredja, Kusnandar ; Nakamichi, Masanori ; Hiranita, Takato ; Tanaka, Hiroyuki ; Shoyama, Yukihiro ; Watanabe, Shigenori ; Yamamoto, Tsuneyuki. / Endocannabinoid system modulates relapse to methamphetamine seeking : Possible mediation by the arachidonic acid cascade. :: Neuropsychopharmacology. 2004 ; 巻 29, 番号 8. pp. 1470-1478.
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